Search results for " methods"

Article 2019’s Top Bioprocessing Trends and What to Expect in 2020
…nes—got attention for its technical and process economic advantages compared with more traditional methods, all the while staying within regulatory guidelines.  Efficiency Improved by New Techn…

Article A Diverse Landscape of Patent Issues Seen in the US, UK, and the EU
These inventions can be claimed as methods for administering/delivering a drug as well as a device for administering the drug. Care need be taken, however, in how these various aspects are claimed (e.…

Article Process Development and Optimization Using the ReadyToProcess WAVE™ 25 Bioreactor System in Dual Mode
Download this application note to learn about the technical feasibility of the Method editor and operations in dual mode (where two parallel cultures are controlled independently) are demonstrated. …

Article Using Software in Process Validation
Software systems have become instrumental as validation expands from analytical methods used for the quality control of drug substances and drug products to computerized systems for clinical trials, l…

Article Cell-Culture Advances Test Bioreactor Performance Models
The evolution of cell-culture technology is driving the need for improvements in modeling solutions. By Cynthia A. Challener  Modeling and simulation are recognized to provide assistance i…

Article Tools and Processes for Mature and Emerging Therapies
The likelihood that manufacturing gene therapies or cell therapies in a cost-effective manner using current manufacturing methods is very unlikely. Speakers at the BIO International convention in …

Article Sephadex™ Size Exclusion Resin Turns 60
Do you know the story behind Sephadex, which enabled today's large-scale production of biopharmaceuticals? An inadvertent discovery in 1959 became the foundation for today's biopharma industry. This i…

Article Single-Use for Downstream Chromatography: Benefit or Hindrance?
Thus, good sanitation methods and familiarity with the most likely microbial contaminant species present in the immediate environment are needed to address bioburden. Using pre-sanitized single-use co…

Article Western Blot Detection: Is Film or a Digital CCD Imager Better?
It is based on building an antibody:protein complex via specific binding of antibodies to proteins immobilized on a membrane and detecting the bound antibody with one of several detection methods. …

Article Leveraging Computational Models of Glycosylation for Biopharma QA
…ions), flux models must be solved using constraint-based linear programming (29,30) or probabilistic methods, such as Markov chain Monte Carlo simulations (31,32). A key advantage of flux-based model…

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