Search results for " cost"
Article
Antibody Production in Microbial Hosts
However, clinical success of mAbs has tremendously increased their demand, and this in turn has fueled interest in other cost-effective alternative production systems such as microbial hosts. Further,…
Article
Aseptic Processing: Keeping it Safe
Negative agency inspection, increasing operating costs, and poor media fill results are among the reasons many manufacturing organizations are deciding to update or replace aging aseptic processing eq…
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Use of Multivariate Data Analysis in Bioprocessing
Singh
BioPharm International
The ever increasing demand of biotherapeutics, together with the pressure to contain healthcare costs have motivated biotech manufacturers to focus on process opti…
Article
Continuous Chromatography: Trends, Definitions and Approaches
Continuous operation can be performed using standard stainless steel systems without problems and potentially at a lower cost. For instance, in the early days of implementation of SUS, an argument was…
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Drug Discovery and Development in India
As a result, Indian pharmaceutical companies have begun to move their operations outside of the country, despite the potentially higher cost. Lupin Pharmaceuticals has set up two research and developm…
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Vaccine Development and Production Challenges Manufacturers
Doctors Without Borders complained that price cuts proposed by Pfizer and GlaxoSmithKline (GSK) were inadequate; manufacturers countered that they were providing their products below cost (1). The dis…
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SEC in the Modern Downstream Purification Process
The low-cost/low-complexity use of SEC resins in single-use technologies would be ideal to alleviate growing economic concerns and would reduce costs by eliminating some of the validation expenses ass…
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Ligand-Binding Assays and the Determination of Biosimilarity
…homogenous no-wash platforms aid in assay transferability, reproducibility, scalability, and overall cost reduction. They are also very robust and meet development criteria, which is equally importan…
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Challenges of Protein Aggregation During Purification
“In particular, resolubilization of insoluble aggregates typically requires extra process steps and can both be very costly and compromising on the overall process yield,” adds Jagschies.
Changing…
Article
Evaluating Design Margin, Edge of Failure and Process
PPM can further be converted into cost or other metrics of interest.
Conclusion
Modern drug development and ICH standards encourage design space generation in new product development. It is a …