Search results for "TFF"
Article
Tools for Continuous Bioprocessing Development
For example, perfusion process development experiments (21) using a 4-L working-volume Wave bag and alternating tangential flow (ATF) or tangential flow filtration (TFF) cell-retention filter, consume…
Article
Extractables in Single-Use Systems Used in ADC Manufacturing, Part 2
We performed extractables studies on single-use chromatography and tangential flow filtration systems using common solvents in ADC manufacturing, DMA and DMSO. The low levels of extractables f…
Webcast
Webinar: Intensifying Downstream Bioprocessing With Continuous Technologies
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-How a single flow through chromatography step can simplify polishing
-The role of single pass TFF as an enabler for intensified bioprocessing
Article
Bioprocess filter selection guide
Filter selection can be a daunting task, and with so many options available, it’s hard to know what is right for your process. This new bioprocess filtration selection guide can help get you o…
Article
Increasing mRNA capabilities and capacity for growing market needs
The rapid development of innovative vaccines allowed for the pharmaceutical industry to deliver its first tools in the fight against the COVID-19 pandemic.
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Article
Setting Up Bioprocessing Systems for Digital Transformation
Meanwhile in downstream processing, chromatography and tangential flow filtration (TFF) systems also gather different, but significant amounts, of data, which can be used to monitor and control proces…
Article
Scaling Up Novel Therapies
Scaling Up Novel Therapies
Platform processes have improved monoclonal antibody scale-up. Can they do the same for personalized therapies?
By Agnes S…
Article
Connected Polishing and Concentration Under One Automation Method
Chromatography and tangential flow filtration (TFF) steps are traditionally performed as separate unit operations in downstream bioprocessing. This work aims to demonstrate the capability of the UNICO…
Article
Single-Use Workflow for Recovery of a Domain Antibody from E. coli Culture Feed in an Automated Manner
This application note demonstrates the performance of the automated ÄKTA™ readyflux single-use filtration system in microfiltration applications. Here, a domain antibody (dAb) expressed in E. col…
Article
Modeling and Miniaturization: Key Topics at Successful HTPD Conference
For instance, Anthony Portolesi and David Smithson, both from Genentech, presented high-throughput TFF for formulation using a Sartorius beta system, and also how static light scattering could be used…