Search results for "cleaning" in Articles / App Notes
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
These technologies provide several advantages over stainless-steel systems, including reduced capital investment, elimination of cleaning in place (CIP), and cleaning validation. These advantages, acc…
Article
A Plastic Pipeline for Commercial Bioprocessing?
…sts, flexibility of system configurations, faster changeover times, the reduction or elimination of cleaning steps and cleaning validation, and a lower risk of cross contamination are recognized as b…
Article
Automation Trend in Fill/Finish Reduces Contamination Risk
This has led to as few human interactions as possible at the fill/finish step, including the loading of raw materials, system changeovers, and cleaning (3).
Adopting automation
Typically, autom…
Article
Single-Use Chromatography: Adapting to Manufacturing Scale
The capital investment is lower, and substantial time savings can be made when eliminating cleaning and cleaning validation procedures. While widely adopted in upstream production processes, what is r…
Article
Sanitization of ÄKTA™ pilot 600 Using Sodium Hydroxide
The results show excellent cleaning efficiency, with a log reduction factor of ≥ 6 for colony forming units (CFUs) of the test microorganisms. Sanitization of the SNAP-connectors using 1 M NaOH was al…
Article
Industry Adoption of Single-Use Systems Remains Low
Sterile-fluid transfer has traditionally been conducted through product piping, stainless-steel vessels, routing manifolds, and valves--all of which requires cleaning and sterilization. In addition, e…
Article
Bioburden Control in the Biopharmaceutical Industry
Protecting against microbiological contamination over the whole manufacturing process grows increasingly important.
By Mostafa Eissa
The biopharmaceutical industry has witn…
Article
Improvements in Protein A Chromatography
To reach 500 cycles, it not only requires a well-developed cleaning regimen but also requires roughly 120 grams of mAb and 250 days of lab experiments. In addition, it would likely lead to the develop…
Article
Single-use Bioreactors Have Reached the Big Time
Expanding applicability
There are, however, some cases where single-use bioreactors may not be the ideal solution, despite their advantages with respect to reduced setup times and cleaning/cleanin…
Article
An Integrated Approach to Ensure the Viral Safety of Biotherapeutics
Such procedures may include aseptic training, purchasing of suitable raw materials, raw material supply-chain management, and cleaning and sanitization, for example.
Biosafety should b…