Search results for " affinity"
Article
Optimizing capture and polishing steps in an rAAV purification process
The chromatography purification described includes affinity capture to maximize recovery with efficient impurity removal.
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Article
Finding the Needle in a High-Dimensional, Information-Rich Data Haystack Can Be Time Consuming
With these tools, scientists can detect and characterize low molecular weight and low affinity compounds binding to their targets.
Improvements in data analysis software have helped to streamline …
Article
Sanitization Opportunities for Protein A Resins
Here, we describe an approach to safely sanitize our new generation bioprocess protein A affinity resin for antibody purification—MabSelect PrismA—with 30 mM PAA combined with NaOH cleaning-in-place r…
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Purifying Tagged Proteins: Learn the Basics
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What is tagged protein purification? When and why should you use it? Learn the basics in our quick guide to tagged protein purification.
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Updating Viral Clearance for New Biologic Modalities
In downstream processing, chromatographic separations leverage interactions through affinity, charge, or hydrophobicity, says Verlenden. Improvements in chromatographic separations designed to maximiz…
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Testa Challenge 2020 Attracts Leading International Bioprocessing Innovators
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Six bioprocessing innovators have successfully completed the inaugural Testa Challenge 2020. Held over an intensive week in the Testa Center located at Cytiva´s Uppsala…
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Platform for Purification of VHH-type Antibody Fragments
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Protein A affinity chromatography resins have been used to purify monoclonal antibodies (mAbs) by the bioprocess industry at all scales for a long time. Howev…
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DiPIA online
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Biacore surface plasmon resonance application specialists are eager to share their experience in assay design, validation, and data evaluation.
Article
Gene Therapies Push Viral Vector Production
Other innovations, such as affinity ligands for specific AAV serotypes are being developed for use with these technologies to further enhance the resolution of the capture step. A major challenge rema…
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2019’s Top Bioprocessing Trends and What to Expect in 2020
2019 proved to be an exciting year for biopharmaceutical developers and process engineers, filled with both advancements and lessons. Considering how far the industry has come, what direction will 2…