Search results for " fragments" in Articles / App Notes
Article
Get Started: Purification of mAb Variants - eLearning
Purification of bsAbs and antibody fragments isn’t as straightforward as for mAbs. These molecules show wider variation in binding affinities and are often more challenging to separate from impurities…
Article
As the therapeutic pipeline diversifies, chromatography toolboxes are expanding.
Development beyond traditional monoclonal antibodies (mAbs) is increasing, and today, we see antibody variants like multispecific and bispecific antibodies and antibody fragments. In mAb proc…
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Chromatography for the Diversified Antibody Pipeline
The antibodies have been there; however, we have also seen the development of fragments, conjugates, and bispecific antibodies. About 25 percent of the biopharmaceuticals are not pure antibodies they …
Article
Get to know: mAb variants - eLearning
Key learnings are:
- Structure and binding domains for antibody variants
- Advantages and disadvantages of different antibody fragments
- Design strategies for bispecific antibodies (bsAbs)
…
Article
Genetic Vaccine Platforms Demonstrate Their Potential
In a pandemic, genetic vaccines offer several advantages over traditional approaches.
By Cynthia A. Challener
For a vaccine to be effective, the components of the disease o…
Article
Can Vaccine Development Be Safely Accelerated?
Leveraging computer technology
NuGenerex Immuno-Oncology is focusing on what von Hofe refers to as the smallest and simplest fragments of the virus needed to produce an immune response. These shor…
Article
Efficient Cleaning-In-Place Methods for Protein-Based Antibody Affinity Chromatography Resins
This whitepaper discusses cleaning of affinity resins intended for use in the purification of monoclonal antibodies and antibody fragments, for example, Fab fragments. Various cleaning strategies and …
Article
Affinity Chromatography Handbook: Vol. 1 Antibodies
The use of recombinant technology opens up the potential to create an infinite number of combinations between immunoglobulins, immunoglobulin fragments, tags and selected proteins, further manipulatin…
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Antibody Purification Handbook
The use of recombinant technology opens up the potential to create an infinite number of combinations between immunoglobulins, immunoglobulin fragments, tags and selected proteins, further manipulatin…
Article
Defining Critical Quality Attributes for Monoclonal Antibody Therapeutic Products
An approach for establishing the CQAs of a mAb product by evaluating impact and uncertainty during risk assessment.
A critical quality attribute (CQA) has been defined as “a physical, chemical, …