Search results for " ultrafiltration"
Article
Extractables Studies for Single Use Systems Used in ADC Manufacturing, Part 1
Single‑use (SU) systems have great potential in antibody‑drug conjugates (ADC) manufacturing. The use of organic solvents in the ADC process might , however, raise questions about potential leac…
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Advancing Single-Use Technology Through Collaboration
By working together to harmonize the highly variable steps within the biopharmaceutical manufacturing process, both end users and suppliers are making strides toward the efficiency and integrity of …
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Modular Manufacturing Platforms for Biologics
While large-scale bioreactor systems may require a traditional facility design, he says that once harvest volumes are concentrated via ultrafiltration, podular processes can resume. “Because it is com…
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Continuous Manufacturing: A Changing Processing Paradigm
Konstantinov writes that in addition to multi-column technology, downstream operations could benefit from novel continuous viral inactivation and ultrafiltration/diafiltration unit operations. To stan…
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The Development and Application of a Monoclonal Antibody Purification Platform
In addition, we must develop new technologies for ultrafiltration to meet the need for high-concentration drugs used for subcutaneous injection. These are just some of the challenges facing the indust…
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Addressing the Challenges in Downstream Processing Today and Tomorrow
Concentrations above 250 g/L have been achieved using ultrafiltration at elevated temperatures (14) and over 500 g/L using a wet-ultrafiltration membrane evaporation method (15) (see Figure 2).
A s…