Search results for " ultrafiltration" in Articles / App Notes
Article
Digitalization: The Route to Biopharma 4.0
For formulation, a model for predicting volumetric concentration factor across single pass tangential flow ultrafiltration (SPTFF) can be used to develop real-time automated monitoring and a control s…
Article
Downstream Processing Continues to Worry CMOs
(Figure courtesy of author)
Chromatography and ultrafiltration
When it comes to specific steps that contribute to downstream-related capacity constraints, chromatography columns continue to be…
Article
Trends in Downstream Bioprocessing
It involves the removal of insoluble cell debris and particulates; product isolation through extraction, adsorption, ultrafiltration, or precipitation; product purification through affinity chromatogr…
Article
Concentration and Buffer Exchange Using the Automated, Single-Use ÄKTA™ readyflux System
This work describes the capabilities of ÄKTA readyflux when used in ultrafiltration/diafiltration (UF/DF) applications. The process was conducted in an automated manner based on methods created …
Article
Automated Concentration and Diafiltration of Multiple siRNA Samples
Once the duplex is confirmed to have minimal excess of either single strand, the siRNA product requires diafiltration and concentration using ultrafiltration methods. These methods remove residual sal…
Article
High-concentration monoclonal antibody drugs: manufacturing challenges
Manufacturing unit operations that are directly impacted by higher concentration formulations range from ultrafiltration to sterile filtration, filling, mixing and storage. Solutions that maintain qua…
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
In addition, because the NevoLine Upstream platform integrates cell culture with in-line midstream operations such as virus clarification, concentration, and ultrafiltration/diafiltration, it delivers…
Article
Setting Up Bioprocessing Systems for Digital Transformation
Digitalization of bioprocessing operations, equipment, and facilities can improve workflow and output, but maintaining data integrity is a concern.
By Feliza Mirasol
The advancement of digit…
Article
Technology Innovations Improve Process Chromatography Performance
The application of more recently developed technologies, such as single-pass ultrafiltration/diafiltration, and as well as continuous virus inactivation step post-Protein A, allows for steps to run in…
Article
Industry Adoption of Single-Use Systems Remains Low
In addition, we have also launched a single-use ÄKTA ReadyFlux ultrafiltration/defiltration system,” he says.
Evolving capacity needs
As the capacity needs of biologic drugs in de…