Search results for " HTPD" in Articles / App Notes
Article
High-Throughput Process Development in Biopharma
… the amount of information available
• Enables reduction of sample amount used
Explore how HTPD can help accelerate the development of downstream processes.
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Q&A with Eric Langer, about the evolution of the role of CMO’s in Bioprocessing
This week Process Development Forum speaks with Eric Langer, President and Managing Partner at BioPlan Associates, and the author of a number of biopharma studies, about the role of CMO’s in Bioproc…
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Optimization of a HIC step for recombinant protein purification
Follow this step-by-step high-throughput process development (HTPD) workflow to determine the optimal resin and initial conditions for hydrophobic interaction chromatography (HIC).
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Utilization of Mechanistic Modeling to Improve Process Development
Mechanistic modeling was also one of the most discussed topics at the recent HTPD conference in Toledo, Spain. An extended report from the conference has now been completed with 15 different presentat…
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Development of Purification for Challenging Fc-Fusion Proteins
The second round of HTPD was performed for one CEX resin under narrower operating ranges in a flow-through mode. The selected resin was a strong cation exchanger with a negatively charged sulfonate gr…
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High-Throughput Process Development Handbook
Time-to-clinic and time-to-market are two key factors for successful biopharmaceutical development. Efficient development of the manufacturing process is a crucial component of the overall project…
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Q&As with Industry Leaders
…artner at BioPlan Associates
3rd HTPD Conference
Phil Lester, Co-Organizer of the HTPD Conference
…
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Developing a HIC polishing step for removal of mAb aggregates
It includes:
- The use of HTPD plates to select the optimal resin as well as running conditions
- The use of a design of experiments (DoE) to optimize the running conditions
- A Monte Carlo simul…
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How to Use Multiwell Plates With Manual Operation
During process development, aspects like robustness, scalability, and GMP production come into play. FDA initiatives such as quality by design (QbD) put demands on better process understan…
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