Search results for " Capto L"
Article
Process Chromatography Selection for Downstream Processing Applications
Affinity resins like Capto L (antigen-binding fragments [Fabs], domain antibodies [dAbs], etc.), heparin, and blue dye-based resins are also used. For peptides, reversed-phase chromatography is anothe…
Article
Updated Ion Exchange Chromatography (IEX) Handbook
The ion exchange chromatography handbook has been updated to include the expanding range of Capto chromatography media for lab- and large-scale protein purification. The update brings Sepharose and …
Poster
Optimizing dynamic binding capacity and aggregate clearance in an mAb polishing step
Capto™ S ImpAct is a strong cation exchange (CIEX) chromatography medium (resin) designed for monoclonal antibody (MAb) polishing steps. In this study, optimization of binding conditions targeting h…
Article
A deep dive into optimizing AAV capture and polishing to maximize both yield and purity
As demand for AAV vectors grows, so does the need for scalable and cost-efficient purification processes. It’s critical to maximize both overall yield and removal of impurities, including empt…
Article
Optimization of a two-step purification method for bispecific antibodies
Bispecific antibodies (bsAbs) have gained increasing interest over recent years because they can bind two antigens, offering unique modes of action compared to monoclonal antibodies. New and i…
Article
Modern plasmid purification process
AcuraBio selects Cytiva's latest two-step purification protocol to offer a productive plasmid DNA service to its customers globally to alleviate supply constraints for mRNA and cell & gene th…
Article
Protein L affinity resin is ready to move to manufacturing
Although protein L affinity resins have been available for more than a decade, insufficient binding capacities and alkaline stability challenges have limited their use in productive manufactur…
Article
Cytiva Invests $500 Million Over 5 Years to Expand Global Capacity
The investment will include new manufacturing lines and increased automation to deliver additional manufacturing capacity.
On Sept. 13, 2020, Cytiva, announced that it is investing $500 million o…
Article
Fundamentals of Hydrophobic Interaction Chromatography
This article explores the fundamentals and applications of hydrophobic interaction chromatography using Capto™ resins to increase productivity.
Click here to read the article.
Poster
Comparison of Three Different Screening Techniques for Predicting Step Elution Conditions for a Cation Exchanger
Screening of chromatographic conditions can be done in several ways, such as 96-well plates, mini-columns, and tips. It is important that the screening can give an indication of the optimal conditio…