Search results for " impurities"

Article The Challenge of Disruptive Technologies in Bioprocessing
…molecules such as ADCs, antibody fragments, and bispecifics are resulting in higher product-specific impurities. Thermo Fisher Scientific aims to address this challenge with a series of commercialize…

Article Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, Cytiva
This week Process Development Forum talks about Protein A with Jonathan Royce, business leader for Cytiva chromatography resins.    mAb purification platforms are very well established, and …

Poster A Next Generation Protein A Chromatography Resin for Improved Productivity and Bioburden Control
mAb production using a Protein A capture step has followed a highly successful synergistic path the last 30 years. There are, however, remaining challenges. • The increased upstream titers in mA…

Article Unifying Continuous Biomanufacturing Operations
The success of a truly integrated continuous processing platform relies on the collaborative efforts of upstream and downstream specialists. By Randi Hernandez When human cells travel throug…

Article Being Thorough When Transferring Technology
For small molecules, analytical testing can verify the exact structure of the molecule and impurities, whereas this is not possible for proteins due to post-translational modifications (glycosylation,…

Article Mechanistic Modeling of Preparative Ion-Exchange Chromatography
By Anurag Rathore, Vijesh Kumar Among the various downstream processing unit operations that are used for purification of biotech products, chromatography is uniquely capable of providing resolu…

Article Improving Process-Scale Chromatography
Lynch stresses, however, that although capacity is an important feature, the capability of a resin to separate the molecule of interest from the other contaminants and impurities is the most important…

Poster Guide to modern BioProcess™ chromatography resins
There is an intermediate step where bulk impurities are removed followed by polishing to achieve a final high-level purity. During method and process development, chromatography resins are selected an…

Article Single-use technologies in downstream process intensification
In bioprocessing, thorough cleaning is critical in order to take full benefit of the resin by removing impurities. When using conventional chromatography solutions, cleaning and cleaning validation …

Article Design and Qualification of Single-Use Systems
…r operational performance criteria, as well as potential chemical interactions and equipment-derived impurities or particulate contaminants that may be introduced into applicable processes and potent…

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