Search results for "Upstream"
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Technology Innovations Improve Process Chromatography Performance
Although significant work has been done in upstream bioprocessing to remove bottlenecks through the implementation of single-use technologies, better characterization of raw materials, and the use of …
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Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The white paper includes a brief discussion around modern vaccine processes, followed by a case study showing the scale-up of upstream and downstream processes for the production of a cell based live …
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Scaling Up Novel Therapies
One way they do this, he says, is by “scaling out,” intensifying processes, for example by using fed-batch and perfusion on the upstream side, and multicolumn operations, whether it’s just higher cycl…
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Modeling and Miniaturization: Key Topics at Successful HTPD Conference
Since then, HTPD in chromatography applications has been well established among most biopharmaceutical companies, but has also expanded to upstream and cell culture screening as well as to formulation…
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Safety Drives Innovation in Animal-Component-Free Cell-Culture Media Technology
However, the reality is that the routine methods used for virus removal and inactivation have not always been sufficient to eliminate all of the upstream process risks presented by viruses. Viral cont…
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CMOs Continue to Improve Overall Biomanufacturing Performance
Separately, 43% of industry respondents reported outsourcing at least some upstream process development activities to some degree, up from just 17.1% back in 2010. Additionally, 41% reported at least …
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Evaluating the Use of Continuous Chromatography
Although significant strides have been made to advance continuous upstream processing, downstream processing has not advanced at the same pace. However, according to Gerstweiler et al., “Research on c…
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Insights and Strategies for Successful Development of Scalable AAV Processes: Part 2 of 2
Topics covered include:
1:00 – The upstream approach for AAV production, such as finding the balance between different parameters in the design of experiments to create a robust production proc…
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Cell-free Expression Systems Pose Cell Culture Alternative
Feliza Mirasol
Among the challenges in upstream bioprocessing is the cellular waste generated as a by-product of cell culture. One approach that potentially offers the benefit of a “cleaner”…
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Leveraging Data for Better Biopharmaceutical Process Control
By Agnes Shanley
Upstream biopharmaceutical manufacturing has always depended on process measurements, because precise levels of nutrients and oxygen must be monitored closely to e…