Search results for "Upstream"
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Tools for Continuous Bioprocessing Development
The industry needs technologies that can enable upstream processes to move quickly and seamlessly between partners, whether internal or external. Currently, cultural challenges and established ways of…
Article
Explore the Process Intensifier App
• Both as a connected operation: what happens when you combine upstream and downstream approaches?
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Top Challenges to Overcome When Developing AAV Processes: Part 1 of 2
Topics covered include:
1:00 – Two main challenges for upstream AAV process development, including which development platform to use and scalability
3:09 – Parameters evaluated for AAV p…
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Setting Up Bioprocessing Systems for Digital Transformation
As John Liddell, chief technologist, Biologics, at CPI indicates, mAb processes can generate significant amounts of data because, in upstream processing, cell culture processes typically run for 14 da…
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Process Development: 2020 Reflections and 2021 Possibilities
Bioprocess Development Forum readers also focused on upstream predictability and how companies are exploring process intensification efforts at every stage of upstream processing, which drives improve…
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Cytiva Introduces the Xcellerex Automated Perfusion System
16, 2020 that it is launching the Xcellerex Automated Perfusion System (APS), a device aimed at simplifying processes and reducing risks when intensifying upstream operations.
Integrated with Cyti…
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Next Generation Bioprocesses: Mapping Roads to the Future
So what are next-generation processes?
These processes overarch the whole manufacturing chain—from cell to molecule and upstream to downstream. They include semi-continuous and continuous approach…
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Moving PAT from Concept to Reality
Upstream focus
Most PAT tools that find wide use today are designed for application in upstream processes. “This focus is in large part due to the fact that initial protein quality and effectivene…
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Achieving Process Balance with Perfusion Bioreactors
The goal, according to Levison, is to intensify the process and reduce overall upstream process time, which delivers even more cost and time savings.
Ensuring process stability
The longer proc…
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State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
For example, our studies have shown rather consistent incremental increases in upstream cell culture titers over the past three decades; and it took well over a decade for single-use equipment to atta…