Search results for "Upstream" in Articles / App Notes
Article
Continuous Processing for the Production of Biopharmaceuticals
The industry already has experience in terms of continuous upstream processing. Perfusion technology has been successfully used for the production of biotherapeutics for more than a decade. In the pas…
Article
Biomanufacturing: Demand for Continuous Bioprocessing Increasing
Continuous processing upstream has been around for decades as perfusion (e.g., fiber-based perfusion bioreactors for fused-cell hybridoma culture in the 1980s). But that’s essentially the only continu…
Article
The New World of Biopharmaceutical Manufacturing
Single-use technology has also precipitated changes in upstream and downstream processing.
Pharmaceutical Technology spoke with Eric Langer, managing partner at BioPlan Associates; John …
Article
Hybrid Bioprocessing: A Q&A with Andrew Sinclair
What could be the main reasons and/or the main drivers that hybrid bioprocessing are being used? Is there a difference between upstream and downstream?
If we look at the key benefits that are attr…
Article
Continuous Manufacturing: A Changing Processing Paradigm
In addition, there is some trepidation surrounding the integration of upstream and downstream processes and the interaction between unit operations, as it is well documented that changes upstream affe…
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
Challener
Upstream viral-vector processes can have significant impacts on downstream purification requirements. The presence of serum, culture harvest viability, turbidity, cell lysis r…
Article
Technology Innovations Improve Process Chromatography Performance
Although significant work has been done in upstream bioprocessing to remove bottlenecks through the implementation of single-use technologies, better characterization of raw materials, and the use of …
Article
Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The white paper includes a brief discussion around modern vaccine processes, followed by a case study showing the scale-up of upstream and downstream processes for the production of a cell based live …
Article
Scaling Up Novel Therapies
One way they do this, he says, is by “scaling out,” intensifying processes, for example by using fed-batch and perfusion on the upstream side, and multicolumn operations, whether it’s just higher cycl…
Article
Modeling and Miniaturization: Key Topics at Successful HTPD Conference
Since then, HTPD in chromatography applications has been well established among most biopharmaceutical companies, but has also expanded to upstream and cell culture screening as well as to formulation…