Search results for "bispecific"
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Applications of Surface Plasmon Resonance for Detection of Bispecific Antibody Activity
One of these promising groups of antibodies is called bispecifics, where one antibody can simultaneously bind to two targets.
Advanced antibody engineering has resulted in the ability to manufactu…
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FDA Provides Guidance on Bispecific Antibody Development Programs
FDA published final guidance on May 24, 2021 to provide industry and stakeholders with recommendations for the development of bispecific antibodies including recommendations for regulatory, quality, n…
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Optimization of a two-step purification method for bispecific antibodies
New and improved antibody bioprocesses and recombination techniques have contributed to a surge in the numbers of bispecific antibody constructs currently in clinical trials.
Alligator Bioscience A…
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Bispecific Antibody Purification: Insights and Case Studies
Here are some industry insights to help you navigate the bispecific jungle.
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Single-Step, Protein A Chromatography Process for Bispecific Antibodies in Early Screening
Learn more about bispecific purification
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Capture of Bispecific Antibodies and Removal of Product-Related Impurities
Many of these variants, especially asymmetric bispecific antibodies, are prone to aggregation or to forming product-related impurities such as homodimers and half antibodies during cell culture. The s…
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Optimization of a Two-Step Purification Method for Bispecific Antibodies
Alligator and Cytiva developed an efficient downstream purification process for a cancer immunotherapy bispecific antibody (bsAb).
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Optimizing KiH bispecific antibody chromatography steps
Bispecific antibodies (bsAbs) are a promising class of therapeutic agents due to their ability to bind to two different types of antigens or two different epitopes on the same antigen. This a…
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Purification strategies for antibody-derived entities: bispecifics and fragments
Here we present strategies for purifying bispecific antibodies and antibody fragments having the molecule type and the impurity profile in mind.
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Selecting Chromatography Resins for Bispecific Antibody Purification
Targeting enhancement with two active antibody arms makes bispecific antibodies (bsAbs) highly attractive for the treatment of cancer and other diseases. Their purification can be more challen…