Search results for " high-throughput"
Article
Addressing the Complex Nature of Downstream Processing with QbD
We have also developed many high-throughput tools applicable to process and product development within upstream, downstream formulations, and analytical development,” MacDonald says.
The benefits …
Article
Moving PAT from Concept to Reality
The ability to characterize proteins in a bioreactor on-line via a reliable, reproducible, rugged, high-precision, and high-throughput liquid chromatography–mass spectrometry (LC–MS) instrument at a c…
Article
Advances in Engineering of Protein-Based APIs
Similarly, miniaturization and high-throughput versions of protein assays will reduce analysis times and enable exploration of wider design spaces. Stevens points to nanofluidic characterization assay…
Resource
HTPD Meeting
The HTPD conference series is the key international forum for the presentation and discussion of topics relevant to high-throughput process development and other approaches to smart PD for biopharmace…
Article
Miniaturization to Become Even More Successful
The industry has turned to high-throughput process development (HTPD) methods—miniaturization, parallelization and automation in particular—to carry out the large number of experiments required for th…
Article
Platform Technologies Improve Protein Expression
Sanofi is also pursuing process intensification for high-throughput, semi-continuous manufacturing in the short term.
Plasmid-Based Expression
Batavia Biosciences’ plasmid-based STEP technolog…
Article
Managing Residual Impurities During Downstream Processing
For DNA detection, Atouf notes that qPCR was included because it is by far the most commonly used technique in the industry due to its high sensitivity, specificity, dynamic range, high-throughput cap…
Article
HTPD: Optimizing a mAb Chromatography Polishing Step
Development of robust purification processes requires significant time and resources. In addition, steadily increasing demands from regulatory authorities for better understanding and control of man…
Article
High Throughput Protein Purification at a Glance
In a blog post site manager Hanna Tegel and research engineers Anne-Sophie Svensson and Annelie Cajander, all from KTH – Royal Institute of Technology, Stockholm, share their knowledge about high-thro…
Article
Improving Process-Scale Chromatography
For example, Cytiva is currently using high-throughput screening techniques to screen hundreds of ligand designs with the goal of further improving process economy and robustness in mAb manufacturing …