Search results for " fragment"
Article
Antibody Production Workflow
Explore the workflow here >>
Antibody-based therapies have evolved beyond monoclonal antibodies (mAbs) to include bispecific antibodies, antibody fragments, antibody-drug conjugates (ADCs), and m…
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The Importance of Process Intensification and PAT for Achieving Real-Time Release
Creativity and collaboration are required to overcome complex method development challenges.
By Kelvin H. Lee and Mark Lies
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Reimagining Affordable Biosimilars
…quadrapole (QqQ), Fourier transform-ion cyclotron resonance (FTICR), Orbitrap, and ion-mobility; and fragmentation by electron-transfer dissociation (ETD) and electron-capture dissociation (ECD) comp…
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Testa Challenge 2020 Attracts Leading International Bioprocessing Innovators
…tart to finish bioprocess run in the Testa facility by producing and purifying a dAb domain antibody fragment. Entrants could concentrate on the whole process or any of the five key stages:
• Pro…
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Gene Therapies Push Viral Vector Production
“The CDMO market is currently fragmented with more new players offering to manufacture vectors. However, the capacity is still not covering the current needs. Capacity increases should resolve the sup…
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Best Practices for Selecting a Top-Quality Cell Line
The nucleic acid fragments that do not contain the target sequence do not get amplified and do not fluoresce. By counting the number of fluorescent droplets versus the total number of droplets, the co…
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Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
Studies and rankings showed that aggregation and Protein A fragmentation were crucial CQAs, Adkins said. Upstream, the most important CQAs include glucose concentration and cell mobility; downstream, …
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Scaling Up Novel Therapies
In addition, he says, it will speed up and allow for screening of a much larger number of variants for mAbs, bispecifics, trispecfics, fragments, and recombinant proteins. For some cell therapies, the…
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Ensuring Viral Safety of Viral Vaccines and Vectors
This method allows simultaneous sequencing of millions of DNA or RNA fragments and requires no prior knowledge of potential virus contaminants (29).
Remove or inactivate viral contaminants downstr…
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The Challenge of Disruptive Technologies in Bioprocessing
In addition, there is a need for new resin chemistries for polishing end product because the bioprocessing of complex therapeutic molecules such as ADCs, antibody fragments, and bispecifics are result…