Search results for "buffer"
Article
Get Confident: Inline Conditioning Control Modes
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In this course, you will learn how to use the control modes of the BioProcess Inline Conditioning (IC) system used for buffer preparation. The control modes are the s…
Resource
Protein A Fiber Chromatography from Research to Scale-up and Manufacturing of Monoclonal Antibodies
Screenings of different buffer conditions and lifetime studies, including hundreds of cycles, can be performed in less than 24 hours. On the large scale, the Protein A fiber operated in a rapid cyclin…
Article
Addressing the Complex Nature of Downstream Processing with QbD
For this kind of step, it is important to understand the process parameters such as load ratio, buffer ranges, as well as resin ligand density when developing the control strategy,” says Malmquist.
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Article
Using Multiple Techniques in Biosimilar Analysis
Similarly, the formulation buffer may include excipients that cause some techniques to fail, or the formulation concentration of the API may be too low to detect using certain techniques. These occasi…
Article
From Darwin to Recombinant Fc Multimers
Joakim Lundkvist from Cytiva presented data from a real-life case study with a plasma fractionator on buffer management, which show significant savings in CAPEX, tank space, floor space, and number of…
Article
Downstream Processing for Cell-Based Therapies
A biological safety cabinet usually is needed for the subsequent resuspension step, which involves discarding spent medium and resuspending in a suitable buffer. This process may be repeated multiple …
Poster
Unlocking the potential for efficiency in downstream bioprocesses
It describes techniques like continuous processing and in-line conditioning buffer preparation, system automation, and more. It also shows how implementation of efficient process designs can overcome …
Article
A Q&A on Bioprocessing Trends and Technologies at INTERPHEX 2016
Did you see any trends in the consumables segment?
The quality and supply of cell-culture media, buffers, and other process liquids was also a popular topic. Demand for custom formulations and pac…
Article
A Platform Approach for the Identity Testing of Multi-Component Cell-Culture Media
Another practical approach for media identification is the use of relatively simple tests for the identification of process buffers (14). In such case, few nonspecific identification tests—such as com…
Article
Continuous Manufacturing: A Changing Processing Paradigm
As the mass of protein to be purified increases, required buffer and elution volumes in batch-capture chromatography increase (8). A continuous capture option could be a good alternative to reduce col…