Search results for "Mabs" in Articles / App Notes
Article
Continuous Manufacturing: A Changing Processing Paradigm
Case studies with mAbs have shown similar yield and purity compared with batch runs and could be associated with an increase in productivity, they note. Other advantages of continuous manufacturing in…
Article
Purification strategies for antibody-derived entities: bispecifics and fragments
Purification platforms used for many monoclonal antibodies (mAbs) need to be adopted for antibody variants to simplify protocols and improve purity and yield. The safety and efficiency requirement of …
Article
Selecting Chromatography Resins for Bispecific Antibody Purification
Their purification can be more challenging than traditional monoclonal antibodies (mAbs), however, due to the increased level of product-related impurities with high similarity to the desired bsAbs. A…
Article
Report from the 6th International HTPD Conference
The QSAR model by Merck has been developed and trained with 10,000 data points from historical data on 40 proteins (mainly mAbs but a few Ab variants) and 51 resins. Calculated descriptors for protein…
Article
Fundamentals of hydrophobic interaction chromatography
…ange of molecules:
* recombinant proteins and peptides
* monoclonal antibodies (mAbs), bispecific mAbs and antibody-drug conjugates (ADC)
* mRNA
* plasmid
New to HIC? Brows…
Article
Maximum Output Starts with Optimized Upstream Processing
Significant growth in the development and manufacturing of biologics—from traditional recombinant proteins and monoclonal antibodies (mAbs) to advanced multispecifics, antibody-drug conjugates, viral …
Article
A Continuous Confidence Boost
Continuous processing of monoclonal antibodies (mAb) could offer a number of advantages, but regulatory uncertainty and upfront investment remain sticking points.
In this case study, Shanghai Henli…
Article
Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
(Figures courtesy of the authors)
Monoclonal antibodies (mAbs) are at present the fastest growing subclass of biopharmaceuticals and have been successfully demonstrated to treat a variety of di…
Article
The Challenge of Disruptive Technologies in Bioprocessing
Demand for mAbs, for example, is expected to increase by one or two orders of magnitude, and it may not be economical to cover this demand increase using current bioprocessing technology, according to…
Article
Multidimensional Scale-Up of a Monoclonal Antibody Capture Step, Using ÄKTA™ pilot 600
The process, performed with MabSelect™ PrismA Protein A chromatography resin, was scaled up 20-fold from a 70 mL HiScale™ 26 column to a 1400 mL AxiChrom™ 100 column. Equivalent mAb recovery and purit…