Search results for "Mabs" in Articles / App Notes
Article
Continued Process Verification for Biopharma Manufacturing
The authors discuss complications of implementing continued process verification and provide recommended approaches.
Oct 1, 2014
By: Jeff Fleming, Robin Payne
BioPharm International
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Article
Concentrating Feed—an Applicable Approach to Improve Antibody Production
Kelley, mAbs. 1 (5) 443-452 (2009).
2. F. Li et al., mAbs. 2 (5) 466-479 (2010).
3. The Merck Index (Merck & Co. Inc., Whitehouse Station, NJ, 13th ed., 2001).
4. P. Hossler et al., Biotec…
Article
2014 Manufacturing Trends and Outlook
…of the respondents reported that their organizations manufacture therapeutic monoclonal antibodies (mAbs); more than 55% of those surveyed said they manufacture protein-based drugs other than mAbs. M…
Article
Optimizing KiH bispecific antibody chromatography steps
However, due to their increased complexity bsAbs often have higher levels of impurities in comparison to monoclonal antibodies (mAbs). This presents challenges to downstream processing.
This web a…
Article
Selected courses from cell culture and downstream process development to scale-up and manufacturing
Develop your skills and those of your teams with training courses designed for researchers, process development scientists, engineers, and manufacturing operators.
Built upon our expertise…
Article
Buffer optimization for separation of bsAb in a capture step using MabSelect™ VL resin
…elution pH, resolution between hetero- and homodimers for bsAb’s, and removal of light chain from mAbs during elution when using MabSelect™ VL protein L resin. The video includes results of these exp…
Article
Video: The solution to smarter column packing
Packing modern chromatography resins at large scale requires a column capable of axial compression to ensure stable, reproducible packed beds. AxiChrom™ columns are low-pressure, axial compressi…
Article
A scalable single-use two-step plasmid purification process
The current global demand for biopharmaceuticals is over USD 300 billion, with an estimated growth of ≥ 12% annually. While MAb processes have become much more efficient, production of mRN…
Article
Top challenges in recombinant protein purification process development
Well, for recombinant proteins, you often don't have an affinity solution, an affinity chromatography solution that can be used, which is very different from mAbs, which do have a great affinity solut…
Article
Chromatography processes for the diversified therapeutic antibody pipeline
Conventional chromatography protocols, used for many traditional mAbs may not be possible to use. Learn about how to adopt chromatography solutions for the diversified molecular pipeline.
Learn mor…