Search results for " single-use" in Articles / App Notes
Article
Process Chromatography: Continuous Optimization
The main driver for new matrices is the wish for pre-sterilized single-use materials that offer both process economy and performance.
As suppliers expand their portfolios of resins to enable effic…
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Hybrid Bioprocessing: A Q&A with Andrew Sinclair
In my view, it's where within the manufacturing process, there are a combination of single-use (SU) materials and re-usable materials in contact with the process and associated fluids. This often refe…
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Accelerated flavivirus vaccine production with modern tools and solutions
By allowing for quick startup and changeover between productions, single-use technologies provide the flexibility required to quickly adapt to market needs. For downstream processing, modern chromatog…
Article
Efficient concentration of a low-titer bovine IgG with high recovery in low volume
The use of ReadyCircuit™ single-use assemblies allowed for aseptic connectivity of the filtration device. Filtration was performed using ReadyToProcess™ hollow fiber filter cartridges. The described …
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Biopharma in 2016: Higher Quality Drugs, Less Expensive Manufacturing
This includes single-use technology, which has been shown to reduce capital and operating costs by 40%-50%,1 and modular and flexible manufacturing systems, which are seen by many as a way for biophar…
Article
Validation of the production of influenza virus in ReadyToProcess WAVE™ 25 bioreactor system
This application note describes the validation of the single-use ReadyToProcess WAVE 25 rocking bioreactor system in production of influenza virus from Vero cells in microcarrier-based cultures. A 2…
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Perfusion in the 21st Century
Perfusion processes are also seen as better suited to meet the needs of flexible, often single-use, multiproduct manufacturing facilities. Such manufacturing sites generally have smaller reactors and …
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Managing Biomanufacturing Capacity Expectations
BioPlan found that the development of more efficient single-use products, better downstream purification technologies, the introduction of continuous downstream operations, and increased modularizatio…
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Aseptic Processing: Keeping it Safe
Other product contact parts, such as pumps or needles, are often dedicated to their specific processes, says Singh, but “even in these operations, single-use systems are being introduced.”
The int…
Article
Risk Assessment and Mitigation in Biopharmaceutical Manufacturing
BioPharm: Does the use of single-use systems (SUS) and/or equipment present any specific challenges or considerations when performing a risk assessment?
AstraZeneca: The use of SUS removes some of…