Search results for " ligand"
Article
Discovering the unknown: How does in silico process development change PD scientists’ work?
So experiments that are performed for modeling aim to capture the dynamics of the interaction between the biomolecules and the ligand. This can be realized by running, for example, linear gradient exp…
Article
Download your Mechanistic Modeling eBook
It also uses adsorption isotherms to quantify how molecules compete for ligands when binding.
Why use mechanistic modeling in downstream process development?
With mechanistic models, proc…
Article
Chromatography innovations for the diverse antibody pipeline
For antibody variants, platform purification protocols for conventional mAb aren’t always providing sufficient outputs — some variants need new ligands, new base matrices, or new chromatography system…
Article
Alkaline stability of Fc and VH3 binding in protein A resins
In this study, we have looked at how different antibody binding sites of a protein A ligand are affected by cleaning in place (CIP). We evaluated NaOH incubation and the effect of performed CIP cycles…
Article
Cytiva Advances Fiber Chromatography Technology with New Launch
Fibro PrismA uses the same chromatography systems, infrastructure, and ligands as resin chromatography, which allows for simple transition into existing biomanufacturing facilities.
The Fibro tech…
Article
Virus-like Particles as Therapeutic Moieties of the Future
Cell targeting
Cell type-specific ligands, such as proteins, aptamers, and small molecules, can be chemically or genetically coupled to the outer surface of VLPs to achieve cell-specific targeting…
Article
Mechanistic Modeling: Current Advantages and Future Opportunities in Biopharmaceutical Process Development
The actual interactions of molecules with the ligands on the resin do not change.
In summary, I am convinced that soon, modeling will be an asset in de-risking drug manufacturing but also the pro…
Article
Studying Resin Variability Using a Process Characterization Kit
Learn how Process Characterization Kits can be used to assess the potential impact of resin ligand density variability on product quality and process performance.
Click here to read mor…
Article
2019’s Top Bioprocessing Trends and What to Expect in 2020
2019 proved to be an exciting year for biopharmaceutical developers and process engineers, filled with both advancements and lessons. Considering how far the industry has come, what direction will 2…
Article
Addressing the Complex Nature of Downstream Processing with QbD
For this kind of step, it is important to understand the process parameters such as load ratio, buffer ranges, as well as resin ligand density when developing the control strategy,” says Malmquist.
…