Search results for " ligand"
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Advances in Engineering of Protein-Based APIs
Advances in Engineering of Protein-Based APIs
New platform technologies, advanced modeling tools, and addressing patient needs are important developments.
By Cynthia A. Challener
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Scaling Up Novel Therapies
Scaling Up Novel Therapies
Platform processes have improved monoclonal antibody scale-up. Can they do the same for personalized therapies?
By Agnes S…
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Selection Guide: Columns and Resins for Antibody Purification and Immunoprecipitation
Resins containing an immobilized ligand (e.g., protein A, protein G, or protein L) are used to capture antibodies and antibody fragments. Affinity purification offers high selectivity. Purity levels a…
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Capacity and Performance of a Next Generation Protein A Chromatography Resin
MabSelect™ PrismA is a protein A resin of which both the ligand and the base matrix have been optimized. The resin exhibits improved capacity over its predecessor MabSelect SuRe™ products, while maint…
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Techniques for Improving Process Development for Exosome-Derived Therapeutics
Founded in 2015, this company’s primary focus is to develop therapeutics with exosomal cargo and engineered surface ligands that can affect diseases, especially those with “undruggable” targets. Speci…
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Affinity Chromatography Handbook in 3 Volumes
Affinity chromatography (AC) separates proteins on the basis of a reversible interaction between a protein (or group of proteins) and a specific ligand coupled to a chromatography matrix. The techni…
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Affinity chromatography Handbook - Vol. 3: Specific Groups of Biomolecules
Affinity chromatography (AC) separates proteins on the basis of a reversible interaction between a protein (or group of proteins) and a specific ligand coupled to a chromatography matrix. The techni…
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Continuous Manufacturing: A Changing Processing Paradigm
To standardize downstream operations, he says one option would be “the rational design of highly specific ligands for the capture step analogous to Protein A in mAb purification” (3).
Costs of ado…
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Optimizing Resin Performance with Disposable Chromatography Solutions
Many resins use the same or similar ligands, but perform quite differently in use, such that manufacturers must balance a number of factors in order to optimize resin performance.
Tingley (Replige…
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Application of Quality by Design to Viral Safety
These materials can be complex, such as animal serum, or purified products, such as porcine-derived trypsin or a recombinant-affinity chromatography ligand. While the quality of these biological raw m…