Search results for " ligand" in Articles / App Notes
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It also uses adsorption isotherms to quantify how molecules compete for ligands when binding.
Why use mechanistic modeling in downstream process development?
With mechanistic models, proc…
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Chromatography innovations for the diverse antibody pipeline
For antibody variants, platform purification protocols for conventional mAb aren’t always providing sufficient outputs — some variants need new ligands, new base matrices, or new chromatography system…
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Alkaline stability of Fc and VH3 binding in protein A resins
In this study, we have looked at how different antibody binding sites of a protein A ligand are affected by cleaning in place (CIP). We evaluated NaOH incubation and the effect of performed CIP cycles…
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Cytiva Advances Fiber Chromatography Technology with New Launch
Fibro PrismA uses the same chromatography systems, infrastructure, and ligands as resin chromatography, which allows for simple transition into existing biomanufacturing facilities.
The Fibro tech…
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Virus-like Particles as Therapeutic Moieties of the Future
Cell targeting
Cell type-specific ligands, such as proteins, aptamers, and small molecules, can be chemically or genetically coupled to the outer surface of VLPs to achieve cell-specific targeting…
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Mechanistic Modeling: Current Advantages and Future Opportunities in Biopharmaceutical Process Development
The actual interactions of molecules with the ligands on the resin do not change.
In summary, I am convinced that soon, modeling will be an asset in de-risking drug manufacturing but also the pro…
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Studying Resin Variability Using a Process Characterization Kit
Learn how Process Characterization Kits can be used to assess the potential impact of resin ligand density variability on product quality and process performance.
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2019’s Top Bioprocessing Trends and What to Expect in 2020
2019 proved to be an exciting year for biopharmaceutical developers and process engineers, filled with both advancements and lessons. Considering how far the industry has come, what direction will 2…
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Addressing the Complex Nature of Downstream Processing with QbD
For this kind of step, it is important to understand the process parameters such as load ratio, buffer ranges, as well as resin ligand density when developing the control strategy,” says Malmquist.
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Advances in Engineering of Protein-Based APIs
Advances in Engineering of Protein-Based APIs
New platform technologies, advanced modeling tools, and addressing patient needs are important developments.
By Cynthia A. Challener
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