Search results for " ligand" in Articles / App Notes
Article
Gene Therapies Push Viral Vector Production
Other innovations, such as affinity ligands for specific AAV serotypes are being developed for use with these technologies to further enhance the resolution of the capture step. A major challenge rema…
Article
On-Demand Webinar: A Route to Deeper Process Understanding—Studying Resin Variability Using a Process Characterization Kit
Chromatography resin attributes, such as ligand density, can affect critical quality attributes (CQAs) as well as process performance depending on the process design and the separation at hand.
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Article
Introducing Process Characterization Kit: New Tools for Gaining Deeper Chromatography Process Understanding
The kits provide critical insights on resin variation within the ligand density specification interval. With these insights, you can develop a solid control strategy for a robust downstream process.
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Article
Making the Move to Continuous Chromatography
He also notes that the advent of new membrane chromatography devices and chromatography media with hydrophilic base beads and high ligand densities will maximize the impact of continuous operations.
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Article
Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
Sophisticated gold-coated electro-responsive substrates have been employed to hydrolyze—under a transient electrical potential—the ether bond that retained the cell-adhesive ligands to which cells are…
Article
mAbs to Watch in 2016
Ixekizumab—Eli Lilly’s ixekizumab is an interleukin-17 drug that works by targeting the IL-17 ligand. This mAb is being developed for the treatment of psoriasis and psoriatic arthritis, and may direct…
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High-Throughput Process Development in an Historical Environment
… resins and how high throughput techniques and different formats were used to identify the effect of ligand density in monoclonal antibody (mAb) purifications. Two different novel multimodal polishin…
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Challenges of Protein Aggregation During Purification
“To avoid the undesired interactions that can lead to aggregation during chromatographic purification, it is important to select the appropriate stationary phase with ligands and backbone structures t…
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Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The bead core contains octylamine ligands that bind a broad range of substances including proteins, peptides, and nucleotide fragments. The multimodal function of the chromatography medium, utilizing …
Article
Discovering the unknown: How does in silico process development change PD scientists’ work?
So experiments that are performed for modeling aim to capture the dynamics of the interaction between the biomolecules and the ligand. This can be realized by running, for example, linear gradient exp…