Search results for " growth"
Article
Optimization of Protein Expression in Escherichia Coli
coli has many advantages—including rapid growth, ease of scale up, and low costs—but it poses challenges as well. Here, the authors discuss some parameters that can influence protein yields and qualit…
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Addressing the Challenges in Downstream Processing Today and Tomorrow
Currently developed biosimilars, such as human growth hormone, insulin, and erythropoietin, are chemically far simpler than mAbs. It is unlikely that blood or plasma-derived products or complex vaccin…
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Sterilization Trends for Single-Use Consumables
The value of the global SU consumables market has already reached several billion dollars and is predicted by multiple market-research firms to continue to expand at a compound annual growth rate of 1…
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Scaling Up an E. coli Upstream Process for Plasmid DNA Production — from 2.5 to 160 L scale Fermenters
coli growth measured as optical density at 600 nm (OD600), plasmid titer, and percentage of produced supercoiled (SC) plasmid DNA was comparable at all culture volumes tested.
Explore th…
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Cell-free Expression Systems Pose Cell Culture Alternative
…cosylation pathways because of cell viability constraints; the inability to completely decouple cell growth from protein synthesis; and inconsistency in batch-to-batch runs based on the inherent vari…
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Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation
By Claire Hill
The biopharmaceutical market continues to expand at a rapid pace and the demand for upstream manufacturing capacity, particularly for growth areas such as viral vectors, is growing …
Article
The Outlook for CMO Outsourcing in 2019
The financial outlook for CMOs is solid, with growth in revenue tracking that of the overall biopharmaceutical sector, which consistently grows at more than 12% annually. CMOs continue to expand capac…
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State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
… industry sector with increasing "manufacturing productivity/efficiency”:
1) Continued healthy growth, generally ≥12% annually, in most every major aspect of the biopharmaceutical industry, wheth…
Article
CDMOs Driving Emerging Bio/Pharma Success
By Jim Miller
Emerging bio/pharmaceutical companies are going through an unprecedented period of opportunity and growth and have contract development and manufacturing organizations…
Article
Industry Adoption of Single-Use Systems Remains Low
… installations the portion of single-use technologies is already between 25% and 50%, and the market growth has been reported to be around 20% in the past three years,” adds Parrish Galliher, chief t…