Search results for " chromatography" in Articles / App Notes
Article
Single-Use for Downstream Chromatography: Benefit or Hindrance?
Hindrance or help?
Many disposable chromatography columns meet cGMP and industry standards, and also offer reproducibility, scalability, speed, ease-of-use, and operational safety.
However, chr…
Article
Mechanistic Modeling of Preparative Ion-Exchange Chromatography
However, development and optimization of a process chromatography step presents a major challenge due to the large number of process parameters that can affect the performance of the step. For example…
Article
Innovative Chromatography Resins Can Improve Purity and Quality
Recent advances in chromatography resins can effectively impact the purification unit operation with positive consequences that reverberate both upstream to the bioreactor and downstream to filtration…
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Next Generation Process Chromatography
So, what can we see at the frontier of process chromatography?
This week, Bioprocess Development Forum spoke with Dr. Oliver Hardick, business leader in the BioProcess group at Cytiva, about the p…
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Continuous Chromatography: Trends, Definitions and Approaches
There is a lot of attention being paid to continuous chromatography, and several different terms are being used: SMB, PCC, MCC. What is your view on the terminology? Is there a difference among them? …
Article
Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, Cytiva
Increasing upstream titers can make the Protein A chromatography process step the rate-limiting step in downstream purification. Protein A chromatography columns are frequently too large, limiting the…
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Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
Purifying these biological products once produced by cells requires a reliable and optimized chromatography process. An advantage in the area of mAbs is the possibility of using a purification platfor…
Article
Insider Recommendations for Getting Started with Mechanistic Modeling of Chromatography
Topics covered include:
0:45 - What is mechanistic modeling of chromatography?
3:47 - Obstacles to implementing mechanistic modelling.
5:10 - Top tips for implementing mechanistic modeling…
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See a chromatography modeling software in action
The typical mechanistic chromatography modeling workflow is an interplay of the tools that you currently use in the lab and the modeling software (Fig 2).
Fig 1. Mechanistic modeling creates…
Article
Improvements in Protein A Chromatography
Bolton recently published a paper “Role of more than 40 years of improvement in Protein A chromatography in the growth of the therapeutic antibody industry,” and also presented at the spring ACS meeti…