Search results for " start" in Articles / App Notes
Article
Technology Innovations Improve Process Chromatography Performance
Among the issues discussed frequently are how one defines where a batch starts and ends and how one can minimize the impact of contamination when something inevitably goes wrong.
“It’s relatively …
Article
Improving mAb Manufacturing Productivity by Optimizing Buffer and Media Prep Process Flow
Innovative approaches, including ready-to-use materials and in-line dilution, can significantly streamline overall bioprocessing operations.
By: Pranav Vengsarkar and Nandu Deorkar
I…
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Biomanufacturing: Demand for Continuous Bioprocessing Increasing
Multi-column, countercurrent, and other variations of continuous chromatography units are just starting to enter the market. The classic and still predominant approach to bioprocessing, both upstream …
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2019’s Top Bioprocessing Trends and What to Expect in 2020
… Challenges for Single-Use Systems
The Good and Bad of Biosimilars
Getting it Right from the Start in the Drug Development Process
Monitoring and Control of Inline Dilution Processes
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Best Practices for Selecting a Top-Quality Cell Line
The strategy, according to Cai, typically starts with the molecule of interest and a codon optimization step to optimize the sequence of the gene(s) of interest. Proprietary vectors are then specifica…
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Methods Accelerate Biosimilar Analysis
One of the reasons for this slow start in biosimilars commercialization is partially due to patent litigation; however, development time and overall costs for biosimilars have certainly played a centr…
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Design Considerations for a Commercial Cell and Gene Therapy Facility
The commercialization of cell and gene therapies has become a reality, prompting deeper considerations of logistics, technology, and design for manufacturing facilities.
By Feliza Mirasol
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Addressing the Complex Nature of Downstream Processing with QbD
In response, we have started testing our lowest operating pressure as part of the viral clearance validation package. Pressure excursions, including what may happen during product recovery buffer flus…
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Sephadex™ Size Exclusion Resin Turns 60
It all started with a paper that began: ”We wish to report a simple and rapid method for the fractionation of water soluble substances.” This is what lead to the discovery.
See video
Article
Science Focus Fuels Successful Process Development for Startups
In addition, development work at Celyad is usually performed with healthy donor materials such as blood and bone marrow taken via apheresis; clinical manufacturing deals with starting materials collec…