Search results for " membranes" in Articles / App Notes
Article
Making the Move to Continuous Chromatography
The aim is the same for all: to achieve a continuous (over) loading of the columns or membranes, and thereby improve the process efficiency through increased resin capacity utilization, according to L…
Article
ADC Development Robust Despite Lackluster Performance
ADC Development Robust Despite Lackluster Performance
Despite the disappointing therapeutic performance of ADCs thus far, the pipeline still boasts promising prospects.
By Feliza…
Article
Downstream Processing for Cell-Based Therapies
By Qasim A. Rafiq, Fernanda Masri
With increasing numbers of advanced therapies—including cell and gene therapies—entering early- and late-stage clinical development, significant focus has been …
Article
Downstream Processing Continues to Worry CMOs
A majority of CMOs are considering:
• Use of high capacity resins
• In-line buffer dilution systems
• Single-use disposable tangential flow filtration (TFF) membranes
• Single use-prep…
Article
Going Small to Achieve Success on the Commercial Scale
The reason often relates to the designs used for small- and large-scale membranes; they are often different, with large-scale membranes having added flutes or pleats or other features that affect thei…
Article
Analyzing Proteins Using SEC, MALS, and UHPLC
Light scattering analysis combined with more rapid size exclusion chromatography improves protein characterization.
The characterization of proteins involves identification of their complex …
Article
The Development and Application of a Monoclonal Antibody Purification Platform
A purification scheme to maximize the efficiency of the purification process and product purity while minimizing the development time for early-phase therapeutic antibodies.
The following ar…
Article
Alternative solutions to separate AAV full and empty capsids using anion exchange
Adeno-associated virus (AAV) is the main vector for gene therapy and there is need for scalable, cost-efficient, and robust chromatography-based purification. Key for a successful process are …
Article
Digitalization: The Route to Biopharma 4.0
These models can capture trends and predict volumetric flow, flux, and pressure across membranes (13).
Implementation of these approaches requires setting up reliable communication protocols an…
Article
Enhancing Resins Addresses Purification Concerns
“Conversely, with production, other methods, such as membranes and monoliths, have been investigated. Although these methods show great promise, further development is still required,” Deorkar says.
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