Search results for "perfusion"
Article
Improving Upstream Predictability
Currently, he says, 50–60% of biopharmaceutical developers and manufacturers have either implemented or are considering use of perfusion for seed train or production bioreactor steps. Used with high c…
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Trends in Single-use Bioreactors
Galliher (Cytiva): The latest innovations include higher-power microbial bioreactors, as well as improved capabilities for continuous perfusion. Single-use stirred-tank fermentation technology has bee…
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Continuous Processing for the Production of Biopharmaceuticals
Perfusion technology has been successfully used for the production of biotherapeutics for more than a decade. In the past few years, researchers have worked toward making various downstream unit opera…
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Evaluating the Use of Continuous Chromatography
…ded continuously, which is a useful approach when the purification step is connected to an upstream perfusion or fed-batch bioreactor, and, by having two or more columns in the loading zone, you can …
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Maximum Output Starts with Optimized Upstream Processing
The use of perfusion processes has enabled even larger throughputs within the same bioreactor volume.
Furthermore, Chilima observes that by using scalable technologies that have representative sca…
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State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
When asked about significant concerns with continuous perfusion versus upstream fed-batch operations, over two-thirds of respondents (68.9%) cited "Process development control challenges" with perfusi…
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Hybrid Bioprocessing: A Q&A with Andrew Sinclair
In the upstream arena, people often refer to perfusion as a variant of continuous. This is a mature technology and the economics are well understood. Where the productivity of the cell line is equival…
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Single-Use Technologies Prove Effective for Viral Vector Process Development
Finally, Ram points out that the use of perfusion in fixed-bed bioreactors is simpler than in traditional stirred tanks because the attachment matrix essentially acts as the cell retention device, whi…
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Developing a Continuous Large-Scale Prefusion Cell Culture Process
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Perfusion processes enable continuous operation over extended periods of time by constantly providing fresh nutrients for the cells and simultaneously removing …
Article
Scaling Up Novel Therapies
One way they do this, he says, is by “scaling out,” intensifying processes, for example by using fed-batch and perfusion on the upstream side, and multicolumn operations, whether it’s just higher cycl…