Search results for " protein" in Articles / App Notes
Article
Detailed agenda for Chromatography + filtration virtual summit
Join Cytiva Chromatography and filtration summit online to learn from presentations, live Q&A, and panel discussions on recent advances in antibody, antibody variants, recombinant proteins, and gene t…
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The Importance of Process Intensification and PAT for Achieving Real-Time Release
Commercially available PAT solutions that will fuel the rise of intensified processing of therapeutic proteins are limited in number, however. Close collaboration between vendors, manufacturers, and h…
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Biosimilar Quality Requirements
In May 2019, the agency published the draft guidance Development of Therapeutic Protein Biosimilars: Comparative Analytical Assessment and Other Quality-Related Considerations (1) and the guidance Con…
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Methods Accelerate Biosimilar Analysis
Intact mass analysis by HR-MS can provide an abundance of information about the integrity of the molecule and glycoforms comprising the protein product or the presence of oxidation, truncation, or oth…
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Addressing the Complex Nature of Downstream Processing with QbD
“For instance, protein A or affinity resins in general, as well as flow through steps, display these properties since these steps in most cases build on a fundamental understanding of the physiochemic…
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Ion Exchange Chromatography: Introducing New Capto™ HiRes Columns
• Designed for the preparation of highly pure proteins and for protein analysis, such as analysis of mAb charge variants.
• Replacing the well-established Mono Q™ and Mono S™ columns—with transiti…
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Combining Purification Techniques in a Multistep Approach
With the right combination of different purification techniques, resins used, and how your methods are set up for a multistep approach, your protein purification will be successful in terms of either …
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Witnessing Major Growth in Next-Generation Antibodies
The global market for next-generation antibodies, including antibody drug conjugates (ADCs), engineered antibodies, bispecific antibodies, antibody fragments, antibody-like proteins and biosimilar ant…
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Perfusion in the 21st Century
Perfusion was first introduced in the 1980s to enable the production of sensitive proteins that degraded when left in bioreactors under batch and fed-batch conditions. Around the same time, continuous…
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Affinity chromatography Handbook - Vol. 3: Specific Groups of Biomolecules
The technique offers high selectivity, hence high resolution, and usually high capacity for the protein(s) of interest. Purification can be in the order of several thousand-fold and recoveries of acti…