Search results for " protein" in Articles / App Notes
Article
The Outlook for CMO Outsourcing in 2019
Rather than just familiar-type recombinant proteins and monoclonal antibodies, CMOs are often the pioneers in terms of manufacturing novel products, including antibodies with novel core structures/bac…
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Scaling Up Novel Therapies
In addition, he says, it will speed up and allow for screening of a much larger number of variants for mAbs, bispecifics, trispecfics, fragments, and recombinant proteins. For some cell therapies, the…
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State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
Survey data show that the lowest costs currently being attained with commercial scale recombinant protein/antibody manufacturing are now in the $100/gram range, with a few of the very largest faciliti…
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Generate an Automated Purification Protocol in Three Steps Using Predefined Methods
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If you are tied to your protein purification system during manual runs, learn how to get started with automated chromatography using predefined methods and add three…
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Queue Up Your Chromatography Steps
To save time and increase throughput, many scientists consider increasing the level of automation in their protein purification workflows. Learn how you can set up automated multi-step protocols uti…
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Automation Trend in Fill/Finish Reduces Contamination Risk
The company installed the new filling line to meet demand for innovative biologics, including vaccines, gene therapies, oncolytic live virus-based therapies, monoclonal antibodies, and recombinant pro…
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Chromatography Scale-Up: Don’t Get Tied Down by Bed Height
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When scaling, you can make better use of existing chromatography columns while avoiding overcapacity.
Keeping a constant residence time is a well-est…
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Making the Move to Continuous Chromatography
“To really maximize productivity, the kinetic effects of adsorption:desorption of protein to the resin become important, and drive demand for more columns in order to operate at high flow rates while …
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Efficient Cleaning-In-Place Methods for Protein-Based Antibody Affinity Chromatography Resins
This whitepaper discusses cleaning of affinity resins intended for use in the purification of monoclonal antibodies and antibody fragments, for example, Fab fragments. Various cleaning strategies and …
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Modeling and Miniaturization: Key Topics at Successful HTPD Conference
This year's clear winner was “Implementation of an Analytical Microfluidic Device for the Quantification of Protein Concentrations in a High-throughput Format” presented by Therese Schermeyer from Kar…