Search results for " Mab"
Article
Use of Multivariate Data Analysis in Bioprocessing
Figure 4: A) Typical platform process for mAb production. B) (B1)Application of multivariate data analysis (MVDA) for establishing process comparability across lab and production scale. (B2) PLS–DA VI…
Article
Tackling Analytical Method Development for ADCs
“Traditional cysteine and lysine chemistry is still a significant part of the ADC regime, but we are seeing a greater breadth of linkers, toxins, mAbs, and classes of conjugation chemistry. New analyt…
Article
High-Throughput Process Development in an Historical Environment
Genentech is said to be working with less than 20 different formulations, developed mainly for mAbs, but these formulations have also been shown to work for other types of target molecules. Instead, t…
Article
Continued Process Verification for Biopharma Manufacturing
Table I is a sample showing the review of variables for inclusion in the model CPV plan for the A-mAb (the conceptual mAb described in references 2 and 3) production-scale bioreaction step. Only some …
Article
Concentrating Feed—an Applicable Approach to Improve Antibody Production
Kelley, mAbs. 1 (5) 443-452 (2009).
2. F. Li et al., mAbs. 2 (5) 466-479 (2010).
3. The Merck Index (Merck & Co. Inc., Whitehouse Station, NJ, 13th ed., 2001).
4. P. Hossler et al., Biotec…
Article
2014 Manufacturing Trends and Outlook
…ibodies (mAbs); more than 55% of those surveyed said they manufacture protein-based drugs other than mAbs. More than 40% of the respondents said their companies manufacture vaccines; 17.7% develop ce…
Article
Optimizing KiH bispecific antibody chromatography steps
… Cytiva developed an optimized capture step for two closely related knob-into-hole (KiH) bsAbs using MabSelect PrismA™ protein A resin which reached a purity of 94%. In addition, two flow-through pol…
Article
Selected courses from cell culture and downstream process development to scale-up and manufacturing
…line development
Bioreactor scaling
Filtration in bioprocessing
Purification of mAb variants
DoE in protein purification
Browse our catalog of free eLearning cours…
Article
Buffer optimization for separation of bsAb in a capture step using MabSelect™ VL resin
… elution pH, resolution between hetero- and homodimers for bsAb’s, and removal of light chain from mAbs during elution when using MabSelect™ VL protein L resin. The video includes results of these ex…
Webcast
Webinar: Intensifying Downstream Bioprocessing With Continuous Technologies
Significant operational improvements can be achieved by intensified continuous processes compared to standard batch processes.
In this webinar we will explore common bottlenecks in downstream pr…