Search results for " Mab"
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Top Tips for Successful Development of Antibody Chromatography Processes
Then, he shares his top tips for addressing challenges associated with mAb aggregates removal and separation of homo and heterodimers.
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Cytiva Advances Fiber Chromatography Technology with New Launch
“Fibro PrismA technology could be the largest improvement to mAb platforms over the past decade. Using Ology Bio’s mAb platform, we have gained two orders of magnitude greater productivity using Fibro…
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Witnessing Major Growth in Next-Generation Antibodies
One involves technologies designed to improve the effector function and/or extend the half-lives of traditional mAbs through modification of the back end, or Fc (fragment crystallizable) region. “This…
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Trends in BioPharma Approvals in 2013
Hospira’s Inflectra (also approved under a separate marketing authorization as Remsima) is even more interesting in that it represents the first ever biosimilar mAb to gain approval in Europe. It is a…
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The Development and Application of a Monoclonal Antibody Purification Platform
The success of this platform in its various stages has been demonstrated for several MAbs representing different IgG classes produced in different cell lines.
Recent advances in mam…
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A Closer Look at Affinity Ligands
Bioprocess scientists and engineers realized the importance of affinity chromatography in purification of mAbs in the early 1980s and identified a small, 42 kD protein (i.e., Protein A) that has excep…
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Setting Up Bioprocessing Systems for Digital Transformation
As John Liddell, chief technologist, Biologics, at CPI indicates, mAb processes can generate significant amounts of data because, in upstream processing, cell culture processes typically run for 14 da…
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Innovative Chromatography Resins Can Improve Purity and Quality
Ongoing downstream challenges
Constraints still remain in downstream processing of mAbs, which continue to be the most successful segment of biological molecules in the market in terms of required…
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Single-Use for Downstream Chromatography: Benefit or Hindrance?
In traditional industrial mAb processes, large volumes of both chromatography resin and buffer are required, which translates into high operating expenses. Because chromatography resins make up a larg…
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Challenges in Cell Harvesting Prompt Enhancements
This results in an added burden to filtration processes, however, which must have the capacity to handle the additive material as well as the mAb product (2).
Other challenges that innovations…