Search results for " Mab" in Articles / App Notes
Article
Continuous Manufacturing: A Changing Processing Paradigm
Employing straight-through processing in mAb purification could significantly improve throughput with a much smaller manufacturing footprint, presenters of the aforementioned webinar conclude. Case st…
Article
Purification strategies for antibody-derived entities: bispecifics and fragments
The safety and efficiency requirement of conventional mAb processes are key also for antibody variants. Here we present strategies for purifying bispecific antibodies and antibody fragments having the…
Article
Selecting Chromatography Resins for Bispecific Antibody Purification
Targeting enhancement with two active antibody arms makes bispecific antibodies (bsAbs) highly attractive for the treatment of cancer and other diseases. Their purification can be more challen…
Article
Report from the 6th International HTPD Conference
The QSAR model by Merck has been developed and trained with 10,000 data points from historical data on 40 proteins (mainly mAbs but a few Ab variants) and 51 resins. Calculated descriptors for protein…
Article
Fundamentals of hydrophobic interaction chromatography
…:
* recombinant proteins and peptides
* monoclonal antibodies (mAbs), bispecific mAbs and antibody-drug conjugates (ADC)
* mRNA
* plasmid
New to HIC? Browse this HIC resour…
Article
Maximum Output Starts with Optimized Upstream Processing
She points to the mAb sector where stainless-steel bioreactors with tens of thousands of liters of capacity were commonly used for cell culture, but today have been replaced with single-use (SU) biore…
Article
A Continuous Confidence Boost
In this case study, Shanghai Henlius Biotech describes its approach to continuous mAb bioprocessing. Insights, experiences, and challenges addressed from their implementation are shared.
Click …
Article
Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
Because nearly all mAb biosimilars are produced in mammalian cells, they exhibit different post translational modifications (PTMs), which results in heterogeneity. This could be attributed to differen…
Article
The Challenge of Disruptive Technologies in Bioprocessing
Demand for mAbs, for example, is expected to increase by one or two orders of magnitude, and it may not be economical to cover this demand increase using current bioprocessing technology, according to…
Article
Multidimensional Scale-Up of a Monoclonal Antibody Capture Step, Using ÄKTA™ pilot 600
In this work, a multidimensional scale-up (change of both column diameter and bed height) of a mAb capture step, using the ÄKTA pilot 600 chromatography system, is demonstrated. Column volume per…