Search results for " Mab" in Articles / App Notes
Article
Cleaning Protein A Resins with 1 M NaOH
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For more information, visit MabSelect Protein A resins
Article
Reducing Cross-Contamination Risks in Process Chromatography
MilliporeSigma, for instance, offers single-use chromatography membranes designed for high mAb throughput that allow the high loadings often obtained in stainless-steel facilities.
Morell…
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Downstream Processing for Cell-Based Therapies
As with the production of mAbs, significant research and development for CGT processes has focused on the intensification of upstream production. For example, several studies have investigated the opt…
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Single-use Bioreactors Have Reached the Big Time
“Examples include traditional vaccines and blockbuster [monoclonal antibody] (mAb) biologics (>2 metric tons of mAb per year); in these cases, single-use bioreactors might not be the most efficient pr…
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Walk Away and Do More Screening Preps
Learn how an ÄKTA pure protein purification system can be modified to increase throughput of mAb purifications and decrease hands-on time.
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Fed-batch supplements to boost cell culture performance
This application note demonstrates the enhanced performance of commonly used cell lines for MAb production when supplemented with HyClone™ cell culture supplements. Cultures of Chinese hamster ovary (…
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Best Practices in Qualification of Single-Use Systems
Figure 1: Typical mAb manufacturing process.
The implementation of SUS usually starts with development of the user requirement specification (URS). Typically, the development engineers at biophar…
Article
Use of Multivariate Data Analysis in Bioprocessing
Figure 4: A) Typical platform process for mAb production. B) (B1)Application of multivariate data analysis (MVDA) for establishing process comparability across lab and production scale. (B2) PLS–DA VI…
Article
Tackling Analytical Method Development for ADCs
“Traditional cysteine and lysine chemistry is still a significant part of the ADC regime, but we are seeing a greater breadth of linkers, toxins, mAbs, and classes of conjugation chemistry. New analyt…
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High-Throughput Process Development in an Historical Environment
Genentech is said to be working with less than 20 different formulations, developed mainly for mAbs, but these formulations have also been shown to work for other types of target molecules. Instead, t…