Search results for " Mab" in Articles / App Notes
Article
Continued Process Verification for Biopharma Manufacturing
Table I is a sample showing the review of variables for inclusion in the model CPV plan for the A-mAb (the conceptual mAb described in references 2 and 3) production-scale bioreaction step. Only some …
Article
Concentrating Feed—an Applicable Approach to Improve Antibody Production
Kelley, mAbs. 1 (5) 443-452 (2009).
2. F. Li et al., mAbs. 2 (5) 466-479 (2010).
3. The Merck Index (Merck & Co. Inc., Whitehouse Station, NJ, 13th ed., 2001).
4. P. Hossler et al., Biotec…
Article
2014 Manufacturing Trends and Outlook
…ibodies (mAbs); more than 55% of those surveyed said they manufacture protein-based drugs other than mAbs. More than 40% of the respondents said their companies manufacture vaccines; 17.7% develop ce…
Article
Optimizing KiH bispecific antibody chromatography steps
… Cytiva developed an optimized capture step for two closely related knob-into-hole (KiH) bsAbs using MabSelect PrismA™ protein A resin which reached a purity of 94%. In addition, two flow-through pol…
Article
Selected courses from cell culture and downstream process development to scale-up and manufacturing
…line development
Bioreactor scaling
Filtration in bioprocessing
Purification of mAb variants
DoE in protein purification
Browse our catalog of free eLearning cours…
Article
Buffer optimization for separation of bsAb in a capture step using MabSelect™ VL resin
… elution pH, resolution between hetero- and homodimers for bsAb’s, and removal of light chain from mAbs during elution when using MabSelect™ VL protein L resin. The video includes results of these ex…
Article
Video: The solution to smarter column packing
Packing modern chromatography resins at large scale requires a column capable of axial compression to ensure stable, reproducible packed beds. AxiChrom™ columns are low-pressure, axial compressi…
Article
A scalable single-use two-step plasmid purification process
While MAb processes have become much more efficient, production of mRNA and viral vectors is still hindered by the requirement for a reliable source of high-quality plasmid DNA (pDNA), which typically…
Article
Top challenges in recombinant protein purification process development
Well, for recombinant proteins, you often don't have an affinity solution, an affinity chromatography solution that can be used, which is very different from mAbs, which do have a great affinity solut…
Article
Chromatography processes for the diversified therapeutic antibody pipeline
Conventional chromatography protocols, used for many traditional mAbs may not be possible to use. Learn about how to adopt chromatography solutions for the diversified molecular pipeline.
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