Search results for " geometry"
Article
Modeling Bioreactor Performance
Challener
Bioreactor design, including the geometry of the tank and impeller and the locations of inlets, has a direct impact on the performance of cell-culture and fermentation processes. Modelin…
Article
Tools for Continuous Bioprocessing Development
The small-scale reactor needn’t have the same shape or geometry.
The industry needs technologies that can enable upstream processes to move quickly and seamlessly between partners, whether internal…
Article
Insider Recommendations for Getting Started with Mechanistic Modeling of Chromatography
That completely captures all of the fluid dynamics and, of course, the internal geometry of the column and system.
Once we've defined these fluid mechanical effects, we can then start to provid…
Article
Using Digital Twins to Model Process Chromatography
The impact of the chromatographic system used, whether lab-scale or manufacturing skid, can be assessed with pulse experiments, or knowledge of the machine’s geometry. Data on column packing quality […
Article
Challenges in Cell Harvesting Prompt Enhancements
The centrifugation process’ clarification efficiency is impacted by harvest parameters including centrifuge feed rate, G-force, bowl geometry, operating pressures, discharge frequency, and ancillary e…
Article
Evaluating Surface Cleanliness Using a Risk-Based Approach
Sampling sites should be defined based upon the geometry and design of the equipment, materials of construction, hard-to-clean areas, and locations that may have a higher risk to product contamination…
Article
Downstream Processing for Cell-Based Therapies
By Qasim A. Rafiq, Fernanda Masri
With increasing numbers of advanced therapies—including cell and gene therapies—entering early- and late-stage clinical development, significant focus has been …
Article
Evaluating E&L Studies for Single-Use Systems
…e execution and the analytics:
• It was difficult to extract small pieces or parts whose geometry was not completely compatible with the selected volume of the extracting solution.
…
Article
Platform Approach Speeds Process Development
A modular cell-culture platform demonstrates accelerated process development.
By Harald Bradl, Jan Bechmann, Benedikt Greulich, Markus Michael Mueller, Patrick Schulz, Thomas Wucherpfennig
C…
Article
Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
The controlled size and geometry of the nanoparticles, as well as their close contact, leads to an intense plasmonic phenomena upon interaction with NIR light—better suited for cell treatment than ult…