Search results for " scalable"
Poster
Adenovirus production in a single-use stirring tank bioreactor system
Adenovirus vectors are attractive delivery systems for vaccines and cancer treatment. Scalable and cost-efficient production technologies are needed to enable manufacturing of safe and efficacious c…
Article
Witnessing Major Growth in Next-Generation Antibodies
Including next-gen antibodies in pharma pipelines is considered essential for future success.
By Cynthia A. Challener
Next-generation antibodies are designed to be more specific and are ofte…
Poster
FlexFactory™ Automation
This automation platform is the foundation of the flexible, configurable, and scalable FlexFactory biomanufacturing solution. The FlexFactory biomanufacturing solution can be delivered as either an in…
Article
Improving Process-Scale Chromatography
Advances in technology are increasing the productivity and efficiency of commercial-scale chromatography bioprocesses.
By Cynthia Challener, PhD
Chromatography is a crucial step in the purif…
Poster
Scale-up of CHO fed-batch cultures in HyClone™ ActiPro™ medium supplemented with Cell Boost™ 7a and 7b
Comparing cell growth and recombinant protein production of multiple Chinese hamster ovary (CHO) cell clones when cultured in HyClone ActiPro basal medium and Cell Boost 7a and 7b feeding supplement…
Article
Generating a Fully Processed Antibody
Both the cell lines and culture processes were easily scalable to larger bioreactors while maintaining good antibody titers and the consistent tag conversion that is required for this unique site-spec…
Poster
Columns up to 1600 mm in diameter packed with protein A chromatography medium using axial mechanical compression
Axial compression allows for optimally packed beds also in the large-scale chromatography column range. Different methods have been developed to pack a broad range of chromatography media (resins) i…
Article
Continuous Processing for the Production of Biopharmaceuticals
The authors review the technologies that may help bioprocessing become a truly continuous operation and present case studies that could contribute to the integration of upstream and downstream platf…
Article
Selecting the Right Viral Clearance Technology
The selection of robust, highly scalable methods that are not affected by variations in feedstocks and consumables is essential for achieving reliable and consistent processes in terms of both their v…
Article
Antibody Fragments and Their Purification by Protein L Affinity Chromatography
…und Protein A affinity chromatography have proven to be fast, efficient, robust, cost-effective, and scalable. Most antibody fragments lack Fc and suitable affinity for Protein A. Adapting proven ant…