Search results for " scalable" in Articles / App Notes
Article
Gene Therapies Push Viral Vector Production
“Therefore,” Chaudhary explains, “the lack of scalable platform technologies for purification has proven to be a bottleneck in downstream processing. In addition, it is important to maintain AAV vecto…
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Platform Approach Speeds Process Development
A modular cell-culture platform demonstrates accelerated process development.
By Harald Bradl, Jan Bechmann, Benedikt Greulich, Markus Michael Mueller, Patrick Schulz, Thomas Wucherpfennig
C…
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Exosome isolation by tangential flow filtration and size exclusion chromatography
However, ultracentrifugation is not easily scalable. We describe an evaluation of purification workflows from three different cell culture supernatants. The workflows we describe are suitable for scal…
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Genetic Vaccine Platforms Demonstrate Their Potential
…t allow the rapid development of a range of vaccines against emerging infectious diseases based on a scalable novel core technology platform. “The process to develop and produce genetic vaccines is h…
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Best Practices for Selecting a Top-Quality Cell Line
It is difficult to rapidly screen more cell types clones to enable the selection of scalable cell lines capable of generating better cell productivity and product quality that are stable over extended…
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Techniques for Improving Process Development for Exosome-Derived Therapeutics
Specifically, Codiak is investigating the delivery of nucleic acids and engineering exosomes that, when combined with a platform production process, can become exosome drug therapeutics that are scala…
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Single-use Bioreactors Have Reached the Big Time
Adds Adams: “single-use bioreactor technology has matured to the point where suppliers now offer large-scale, robust, well-characterized products that are reliable, scalable, and often preferred over …
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Considerations in depth filter scale-up
Depth filters are widely used in the biopharmaceutical industry. They are typically made of a mixture of cellulose, filter aids, and a binder. These components can be milled and mixed in diffe…
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A deep dive into optimizing AAV capture and polishing to maximize both yield and purity
To meet these needs, Cytiva developed scalable capture and polishing chromatography steps for recombinant AAV (rAAV). The affinity capture step maximizes recovery and efficiently removes impurities.
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mRNA: The Messenger - mRNA Product Purification
Explore the mRNA universe with Cytiva.
Join us for part 4 of mRNA : the messenger, where we discuss key considerations for the purification of the mRNA product, including the various m…