Search results for "antibody" in Articles / App Notes
Article
Bispecific Antibodies are Moving from Research to Clinical Development
With recent approvals of bispecific antibodies, these complex molecules are fast moving out of the research box and into clinical pipelines.
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Article
What If You Could Remove Your Antibody Aggregates Already in the Protein A Step?
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In this study, the potential of Protein A chromatography to separate antibody monomer from HMW species was investigated. A design of experiments approach…
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Webinar On Demand: Expanding SPR Uses in Antibody Effector Function Determination
Stuart Knowling at Antibody Analytics, Glasgow, shares case-studies illustrating how SPR is applied orthogonally in the workflow and successfully used to develop safe and efficient products in an econ…
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High-concentration monoclonal antibody drugs: manufacturing challenges
The growth in the formulation of drugs suitable for delivery by subcutaneous (Sub-C) injection highlights manufacturing challenges associated with the higher concentration of active ingredient…
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Multidimensional Scale-Up of a Monoclonal Antibody Capture Step, Using ÄKTA™ pilot 600
Fast and efficient process development and scale-up contributes to a shortened time to market. In this work, a multidimensional scale-up (change of both column diameter and bed height) of a mAb capt…
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Quality by design for biotechnology products—part 1
Switching the isotype of an antibody product to gain desired effector functions is one approach that has been practiced. In some cases, an IgG1 isotype is ideal for cell killing, whereas IgG2 is a fav…
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Addressing the Challenges in Downstream Processing Today and Tomorrow
In the future, mAbs may represent a smaller percentage of the pipeline as portfolios concentrate more on development of antibody fragments, nanobodies, biosimilar protein therapeutics, conjugated prot…
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Host-Cell Protein Measurement and Control
In the case of an immunoassay, a polyclonal antibody (pAb) used in the test is generated by immunization with a preparation of a production cell minus the product-coding gene, fusion partners, or othe…
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A Closer Look at Affinity Ligands
Other examples include antibody/antigen, enzyme/substrate, and enzyme/inhibitor interactions. The degree of purification achieved by affinity purification can be quite high depending on the specificit…
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Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
Fc receptors can be activating, or inhibitory, or without any effect in antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Characterizing these highly complex…