Search results for " yield" in Articles / App Notes
Article
Reviewing the Importance of Biosimilarity and Interchangeability
Stamm emphasizes that each type of study yields required data as explained in the following sections.
Biosimilarity studies
Comparative analytical data. According to Stamm, biosimilarity…
Article
Introducing Supor Prime Filters: A Filtration Solution for High-Concentration Therapies
In a highly concentrated drug, every drop counts so you can’t afford to sacrifice yield.
You can confidently meet this challenge with Supor™ Prime filters. With twice the throughput, when compared…
Article
Guide for selecting affinity resins for mAbs, bsAbs, and antibody fragments
These target molecules need to be purified to reach required purity and yield.
Selecting an affinity resin for the diverse range of antibodies can be overwhelming. But don’t worry, in this selecti…
Article
Digitalization: The Route to Biopharma 4.0
In two-column capture chromatography, dynamic control can be obtained using adaptive model-based control strategy that led to process yield of more than 85%. The data from high performance liquid chro…
Article
Report from the 12th Plasma Product Biotechnology Forum
The model output was a prediction of yield and purification rate, and the input included feed flowrate, conductivity, column loading, and total protein concentration. One of the conclusions from the s…
Article
Remote Monitoring and Big Data Advance Upstream Automation
Hybrid models have also been used for predicting yields and endpoints with the integration of optimization algorithms for model predictive control in APC strategies,” he comments.
Such innovations…
Article
Mapping a Route for Cell and Gene Therapy Process Development
Statistically relevant measurements must be repeated many times to improve process yields and reduce manufacturing cost, which adds cost and time to the development process,” Lamproye observes. He poi…
Article
Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
So far, however, research has found that full-out production mode offers a better business case for embracing RTR, as does the potential for using a validated approach for another new product if yield…
Article
Leveraging Computational Models of Glycosylation for Biopharma QA
During cell culture, even subtle variations in nutrient availability, dissolved oxygen, temperature, ammonia, and pH may impact the intracellular process of glycosylation (1,3) and yield product that …
Article
Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
Biosimilar two exhibited comparable affinity for binding to FcγRIIIa with respect to Ristova, but others yielded lower values.
Case study: II Binding kinetics of GCS-F biosimilars a…