Search results for " yield" in Articles / App Notes
Article
Considerations for Improving Outcome in Biopharmaceutical Process Development
For example, things like streamlining operations, optimizing titers and yields, evaluating cell lines and cell culture media, and controlling raw material variability can play a pivotal role in obtain…
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Towards a Better Process Outcome
Considerations for improving outcome in biopharmaceutical process development.
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Improving Lentiviral Vector Downstream Processing Workflows
However, these downstream workflows are long, require substantial manual labor, and suffer from low yields of infectious virus. This article discusses process development pain points of a modern workf…
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How to Adapt Biomanufacturing Processes
As the need for more complex molecules drives a new era of biomanufacturing, there is an increased focus on developing processes with improved security, yield, and process economy. Companies working…
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Methods Accelerate Biosimilar Analysis
It is worth noting that IM has also been used for top-down analysis of proteins, even when coupled with medium-resolution mass spectrometers, yielding two-dimensional spectra. By means of two new data…
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Monitoring and Control of Inline Dilution Processes
Selecting a strategy
A potential deviation during inline buffer dilution can risk the product quality or yield. When choosing a control solution, therefore, it is critical to consider what…
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Design Considerations for a Commercial Cell and Gene Therapy Facility
For biologics and viral vectors, the cells are a byproduct of production and, thus, often get lysed and discarded in the downstream process, which is designed to optimize both the yield and the purity…
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Addressing the Complex Nature of Downstream Processing with QbD
We have adopted a risk mitigation strategy in response: we no longer buffer flush our nanofilters to recover the remaining product, essentially taking a yield loss on the step to ensure a quality pro…
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Moving PAT from Concept to Reality
“Trace metals, glucose, lactate, pH, DO, amino acid content, glycosylation profiles, and HCPs must be measured to monitor the process and enable feedback/feedforward control to optimize yield (in-line…
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What’s New in Upstream Technologies
“Optimized mammalian processes are yielding higher cell densities and more product than ever,” said Cristy Botens, product manager of Bioprocessing, Distek, in a March 21, 2019 company press release. …