Search results for " Capto"
Article
Process Chromatography Selection for Downstream Processing Applications
Affinity resins like Capto L (antigen-binding fragments [Fabs], domain antibodies [dAbs], etc.), heparin, and blue dye-based resins are also used. For peptides, reversed-phase chromatography is anothe…
Article
Updated Ion Exchange Chromatography (IEX) Handbook
The update brings Sepharose and Capto IEX media together in the same book and the contents will ensure you get the most from your purification runs.
In addition to a new chapter on large-scale pur…
Poster
Optimizing dynamic binding capacity and aggregate clearance in an mAb polishing step
Capto™ S ImpAct is a strong cation exchange (CIEX) chromatography medium (resin) designed for monoclonal antibody (MAb) polishing steps. In this study, optimization of binding conditions targeting h…
Article
A deep dive into optimizing AAV capture and polishing to maximize both yield and purity
…ls – and ways to overcome them
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Article
Optimization of a two-step purification method for bispecific antibodies
Bispecific antibodies (bsAbs) have gained increasing interest over recent years because they can bind two antigens, offering unique modes of action compared to monoclonal antibodies. New and i…
Article
Modern plasmid purification process
AcuraBio selects Cytiva's latest two-step purification protocol to offer a productive plasmid DNA service to its customers globally to alleviate supply constraints for mRNA and cell & gene th…
Article
Protein L affinity resin is ready to move to manufacturing
The MabSelect™ VL protein L resin now offers improved alkaline stability compared to Capto™ L resin and a two-fold or more increase in dynamic binding capacity (DBC) in certain applications. After com…
Article
Cytiva Invests $500 Million Over 5 Years to Expand Global Capacity
The manufacturing capacity of Cytiva's MabSelect and Capto chromatography product platforms has also doubled as part of a $70-million-per-year (2017–2022) investment in capacity gains and a facility m…
Article
Fundamentals of Hydrophobic Interaction Chromatography
This article explores the fundamentals and applications of hydrophobic interaction chromatography using Capto™ resins to increase productivity.
Click here to read the article.
Poster
Comparison of Three Different Screening Techniques for Predicting Step Elution Conditions for a Cation Exchanger
The aim of this study was to investigate conditions for reduction of host cell proteins (HCP) on a strong cation exchanger, Capto™ S ImpAct. Three different screening techniques using PreDictor™ plate…