Search results for "bioreactors"
Article
Implementation of Raw Material Control Strategies in the Manufacture of Single-Use Bioprocessing Containers
The authors review efforts to limit polymer degradation without significantly impeding cell growth.
Jan 01, 2015
By Sara Ullsten, Shujian Yi, Jeffrey Carter, Eva Lindskog, Pokon Ganguli, Her…
Article
Improving PAT for Biologics
The complexity of biopharma processes requires innovative solutions.
Dec 01, 2014
By Cynthia Challener, PhD
BioPharm International
A key component of the quality-by-design (QbD) ap…
Article
Stirring up the fermentation game
Bioreactors designed for production in mammalian culture fall short of meeting these unique requirements, for example in terms of oxygen transfer capacity and temperature control. The Xcellerex XDR-50…
Article
Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
This case study shows that single-use equipment, including disposable cell culture bioreactors, pre-packed chromatography columns, and filters, can replace traditional equipment, including stainless s…
Article
A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAbs at Large Scale
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We have developed a reliable small-scale model for a monoclonal antibody (mAb) perfusion process using TPP® TubeSpin® Bioreactor tubes and the ReadyToProcess WAVE 25 R…
Article
Remote Monitoring and Big Data Advance Upstream Automation
“Longer term there will be sufficient established PAT solutions, particularly in upstream bioprocessing, to have fully ‘lights-out’ manufacturing, with samples pulled automatically from bioreactors an…
Article
The Importance of Process Intensification and PAT for Achieving Real-Time Release
As the industry has matured, effective manufacturing platforms and analytical tools and technologies appropriate for fed-batch manufacturing in stainless-steel or single-use bioreactors have also adva…
Article
Moving PAT from Concept to Reality
In bioreactors, in-line sensors measure pH, temperature, dissolved oxygen (DO), and carbon dioxide; in-line optical sensors (Raman, NIR) are coupled with multivariate modeling to measure metabolites. …
Article
Process Development: What May Lie Ahead in 2018?
Single-use bioreactors, for instance, are increasingly available from a host of vendors, and suppliers of such technology have made “significant advances in film technologies, bioreactor designs, stir…
Article
Platform Technologies Improve Protein Expression
He points to the use of high-cell-density, fixed-bed bioreactors for adherent cell culture as an exciting new development. “With these bioreactors, it is possible to increase cell densities from 10-20…