Search results for " bispecifics"
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Bispecific Antibodies are Moving from Research to Clinical Development
With recent approvals of bispecific antibodies, these complex molecules are fast moving out of the research box and into clinical pipelines.
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Witnessing Major Growth in Next-Generation Antibodies
For instance, for bispecifics consisting of multiple heavy and light chains, it is essential to ensure that the right components are connected together, according to de Fougerolles. The synthesis of t…
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A Look at the Affinity Chromatography Landscape
A Look at the Affinity Chromatography Landscape
New ligands are being developed to meet the separation and purification needs of next-gen biologics.
By Cynthia A. Challener
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Advances in Engineering of Protein-Based APIs
Bi/multispecific proteins
Bispecific antibodies are an important emerging area in advancing protein engineering for pharmaceutical products, and several bispecifics based on immunoglobulin scaffol…
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Chromatography for the Diversified Antibody Pipeline
The biopharmaceutical industry is engineering for separation by making the bispecifics a heterogenic one—which is different chains to the pair that you can make a whole construct. If there is electros…
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Top Tips for Successful Development of Antibody Chromatography Processes
In this interview, Jakob Liderfelt, Product Manager at Cytiva, discusses main challenges faced during chromatography process development for mAbs and mAb variants such as fragments and bispecific a…
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Best Practices for Selecting a Top-Quality Cell Line
Irina Shi - Stock.Adobe.com
Leveraging automation and a step-by-step approach are keys to success.
By Cynthia A. Challener
Cell lines determine the performanc…
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Guide for selecting affinity resins for mAbs, bsAbs, and antibody fragments
Development of antibody-derived molecules are increasing. Today, molecules such as bispecific antibody (bsAb) and antibody fragments such as Fab, scFv, and VHH are seen in labs all over the w…
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As the therapeutic pipeline diversifies, chromatography toolboxes are expanding.
Development beyond traditional monoclonal antibodies (mAbs) is increasing, and today, we see antibody variants like multispecific and bispecific antibodies and antibody fragments. In mAb proc…
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Get to know: mAb variants - eLearning
The diversity of antibody variants in the biotherapeutics pipeline are increasing with a growing interest for molecules like antibody fragments and bispecific antibodies (bsAbs). Cytiva has pu…