Search results for " scaling" in Articles / App Notes

Article Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
The necessity to detach cells from a culture substrate during cell harvesting remains one of the most challenging steps in a cell-culture process. By Marcos Simon, Juan J. Giner-Casares Cell…

Article SEC in the Modern Downstream Purification Process
Mar 01, 2015 By R. Christopher Manzari, J. Kevin O'Donnell BioPharm International Volume 3, Issue 28 Since the introduction of commercial chromatography resins approximately six de…

Article Automated Concentration and Diafiltration of Multiple siRNA Samples
A team of scientists collaborated on a project to transfer a conventional manual concentration/diafiltration process for siRNA production.  ABSTRACT The use of small-interf…

Article Explore ÄKTA pilot 600 in 3D
Cost and speed are critical components in biomanufacturing. See how ÄKTA pilot™ 600 supports scale-up from process development to GMP clinical scale. Explore this ÄKTA™ system in…

Article Discovering the unknown: How does in silico process development change PD scientists’ work?
So moreover, mechanistic models can be of great help when scaling up. A lot of the effects of the thermodynamics that are happening inside the chromatography column are scale independent. Therefore, i…

Article Digitalization: The Route to Biopharma 4.0
Industry 4.0, also known as the Fourth Industrial Revolution (4IR), will result in the digital transformation of the manufacturing sector. It is propelled by transformative trends such as the prolif…

Article FAQ: Scale-up and scale-down with mechanistic modeling
A mechanistic model can simplify your process development projects. The model eases scale-up and scale-down between lab scale and production scale. To apply model-based scale-up and scale-down…

Article Common Challenges in Cross-Functional Process Development
…wnstream processes be developed concurrently or separately? 3:02 – Factors to consider when scaling up a process 4:32 – Factors to consider when scaling out a process 6:05 – Chal…

Article Strategizing for Rapid Changeovers in Biologics Manufacturing
Olivier Le Moal/Stock.Adobe.com By Cynthia A. Challener  Facility and equipment design are important, but the team and its experience matter most. Through its Operation Warp Speed pro…

Article Technology Innovations Improve Process Chromatography Performance
As technology matures, inefficiencies and process limitations in downstream process chromatography are improved. By Feliza Mirasol Selecting an appropriate separation technology fo…

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