Search results for "downstream"
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Improving PAT for Biologics
Upstream and downstream
Although upstream processes tend to be more challenging and the sources of variability (raw materials and process) are reduced in downstream processes (e.g., after Protein …
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Application of Quality by Design to Viral Safety
These measures may be optimized to reduce small, non-enveloped viruses, such as parvoviruses, that may be difficult to inactivate or remove in the downstream process. Upstream clearance steps may also…
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Predicting Progress in Protein Aggregation
As the development of biologic drugs based on antibodies and other protein/peptide molecules continues apace, the control and prevention of aggregation during manufacturing, downstream processing, for…
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Comparing Protein A Resins for Monoclonal Antibody Purification
As a consequence, downstream processing must accept and handle higher titers of mAbs in harvested cell-culture fluid (HCCF), and vendors of mAb purification technologies must develop chromatography re…
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Automated Concentration and Diafiltration of Multiple siRNA Samples
…d to analyze the quality of the starting feed material and to assign lot specifications for further downstream purification.
The ssRNA product is purified using an anion-exchange chromatog…
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Instructional Videos for Bioprocess Equipment
Upskill your use of Cytiva equipment
To get the most performance out of your bioprocess equipment, sometimes you need a refresher training. Cytiva offers free on-demand instructional vide…
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Filtration methods to overcome new challenges in viral safety
Read our article which summarizes the recent virus filtration regulatory changes in PDA Technical Report No. 41 and ICH Q5A, and outlines the detailed mechanisms governing effective virus filt…
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Exosome isolation by tangential flow filtration and size exclusion chromatography
We demonstrate a scalable workflow for the isolation of exosomes—a type of extracellular vesicle with significant potential for targeted drug/gene delivery. For research and development and di…
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Save the date for HTPD 2025
We are pleased to announce the 7th International Conference devoted to High-Throughput Process Development (HTPD) and smart PD, to be held May 26–29 2025 in Uppsala, Sweden.
The program and…
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Top Tips for Successful Development of Antibody Chromatography Processes
I'm really looking forward to having a discussion with you about downstream processing and some of the challenges, in terms of producing these therapies.
First and foremost, because no drug …