Search results for "downstream"
Article
Exploring the world of antibodies: mAbs, Fabs, dAbs, and bsAbs
There is a vast array of antibody variants, including multispecific (msAb), bispecific antibodies (bsAb), antibody fragments (Fab, dAb, scFv), and antibody-drug conjugates (ADC). But with this…
Article
Video: Standardize recombinant protein purification process development
Cytiva™ Protein Select™ resin is an affinity chromatography resin for purifying recombinant proteins using the self-cleaving Cytiva Protein Select tag. During an affinity step performed with C…
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A deep dive into optimizing AAV capture and polishing to maximize both yield and purity
As demand for AAV vectors grows, so does the need for scalable and cost-efficient purification processes. It’s critical to maximize both overall yield and removal of impurities, including empt…
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Report from the 6th International HTPD Conference
Learn more about the GoSilico™ chromatography modeling software
HTPD is used beyond downstream today
As one proof point that HTPD is not only a downstream approach today, the keynote lec…
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Digitalization: The Route to Biopharma 4.0
Similar studies have also been conducted in downstream processing unit operation. Data-driven models have been used for predicting product recovery and optimization (8). Recently, a hybrid modeling ap…
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Master the basics of UNICORN™ method editing with a free online course
This free interactive course explains how to create and edit methods in
UNICORN™ software for ÄKTA™ chromatography systems.
Review the basics and learn how to use predefined phases…
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Mechanistic modeling quiz: Test your knowledge
Mechanistic models make it possible to create computer simulations of chromatograms. The simulations are based on physiochemical phenomena known to occur in chromatography. The benefit of in …
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Antibody purification quiz
How well do you know antibodies and antibody purification?
Test your knowledge and gain insights in the purification of antibody variants – bsAbs, Fab, dAbs.
Article
Accelerating CMC - The future of process development is in silico
Presented by Per Liden, General Manager, GoSilico at Cytiva.
Simulation for in silico process development is becoming a viable option to reduce the time needed for chemicals, manufacturin…
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Developing a HIC polishing step for removal of mAb aggregates
This article describes the development of a flow-through (FT) polishing step using hydrophobic interaction chromatography (HIC) to remove mAb aggregates.
It includes:
- The use of HTPD plate…