Search results for "downstream"
Article
Improving Process-Scale Chromatography
By Cynthia Challener, PhD
Chromatography is a crucial step in the purification of biopharmaceuticals and accounts for a significant portion of downstream processing efforts (time and cost) for bio…
Article
Host-Cell Protein Measurement and Control
The risks associated with HCPs are often assessed by a combination of downstream process capabilities, residual HCPs levels, the (maximum) dose, route of administration, dosing frequency, toxicologica…
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Enhancing Resins Addresses Purification Concerns
Resins have been seen as one tool that can address the purification needs of new COVID-19 vaccines as well as the existing challenges in the downstream processing of increasingly complex biologic moda…
Article
Gene Therapies Push Viral Vector Production
…y processing time in manufacturing and the complexity of such a process results in a more expensive downstream purification procedure and ultimately, cumulative yield losses. “Therefore,” Chaudhary e…
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Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
Current survey data continue to show that downstream operations still are struggling to keep up with improvements in upstream output, so downtime with upstream versus downstream equipment is normal.
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Reconciling Sensor Communication Gaps
The desirability of platform purification, best exemplified in monoclonal antibody (mAb) downstream processing, simultaneously creates and reduces the need for extensive downstream monitoring. Platfor…
Article
Scaling Up Novel Therapies
… difficult pieces of equipment to scale up, says Fredrik Lundström, product manager for bioprocess downstream hardware with Cytiva. Use of digital modeling is helping developers understand processes …
Article
Ensuring Viral Safety of Viral Vaccines and Vectors
The biotechnology industry utilizes this technology to ensure viral clearance in downstream processing. Currently, optimized filters are considered for the filtration of thermo-sensitive raw materials…
Article
Analyzing Proteins Using SEC, MALS, and UHPLC
The combination of SEC with downstream light scattering analysis and the development of columns that can be used for ultra high-pressure liquid chromatography (UHPLC)-based SEC are overcoming many of …
Article
A Look at the Affinity Chromatography Landscape
…abling increased process intensification and throughput, according to Michael Murray, a director of downstream process development with Fujifilm Diosynth Biotechnologies. He points to engineered anti…